Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4
Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Wu D, Simon M, Kano M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4. Progress In Brain Research 2000, 124: 31-48. PMID: 10943115, DOI: 10.1016/s0079-6123(00)24006-5.Peer-Reviewed Original ResearchAge FactorsAnimalsAtaxiaCell SizeCerebellumExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsIsoenzymesMiceMice, Neurologic MutantsMicroscopy, ElectronNerve FibersOrgan Culture TechniquesPhospholipase C betaPurkinje CellsRNA, MessengerSignal TransductionSynapsesType C Phospholipases