α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor
Krasnoperov V, Bittner M, Beavis R, Kuang Y, Salnikow K, Chepurny O, Little A, Plotnikov A, Wu D, Holz R, Petrenko A. α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor. Neuron 1997, 18: 925-937. PMID: 9208860, DOI: 10.1016/s0896-6273(00)80332-3.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBrain ChemistryCalciumCattleChromaffin GranulesCloning, MolecularCOS CellsDimerizationExocytosisGTP-Binding ProteinsMembrane ProteinsMolecular Sequence DataProtein PrecursorsQa-SNARE ProteinsRatsReceptors, Cell SurfaceReceptors, PeptideRecombinant ProteinsSensory Receptor CellsSequence AlignmentSequence Homology, Amino AcidSignal TransductionSpider VenomsTissue DistributionConceptsG protein-coupled receptorsAlpha-latrotoxin receptorNeuronal G protein-coupled receptorNovel orphan G-protein-coupled receptorI alphaCalcium-independent receptorSecretin receptor familyOrphan G protein-coupled receptorRegulation of neurosecretionEndogenous proteolytic cleavageMolecular cloningPrecursor polypeptideSerpentine receptorsCIRLFusion complexExtracellular bindingAlpha-LatrotoxinFunctional expressionReceptor familyProteolytic cleavagePresynaptic receptorsAffinity columnNeurotransmitter releaseStable complexesPresynaptic neurotoxins