2001
Gα16 Couples Chemoattractant Receptors to NF-κB Activation
Yang M, Sang H, Rahman A, Wu D, Malik A, Ye R. Gα16 Couples Chemoattractant Receptors to NF-κB Activation. The Journal Of Immunology 2001, 166: 6885-6892. PMID: 11359849, DOI: 10.4049/jimmunol.166.11.6885.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAmino Acid SubstitutionCell NucleusEnzyme ActivationGenes, ReporterGlutamineGTP-Binding Protein alpha Subunits, Gq-G11HeLa CellsHeterotrimeric GTP-Binding ProteinsHumansIsoenzymesLeucineLuciferasesNF-kappa BPhospholipase C betaReceptors, ChemokineReceptors, Formyl PeptideReceptors, ImmunologicReceptors, PeptideSignal TransductionTrans-ActivatorsTransfectionType C PhospholipasesConceptsNF-kappaB activationFormyl peptide receptorChemoattractant receptorsPeptide receptorCXC chemokine receptor 2NF-kappaB.Chemokine receptor 2Regulatory protein alpha subunitNF-κB activationLuciferase activityProtein kinase CKappaB-luciferase activityPhosphorylation of IkappaBalphaPhospholipase C-beta activityC3a receptorReceptor 2Seven-membrane-spanning receptorsAgonist stimulationConventional PKC isoformsPharmacological inhibitorsLuciferase reporterReceptorsHemopoietic cellsProtein alpha subunitsCell model system
2000
Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4
Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Wu D, Simon M, Kano M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4. Progress In Brain Research 2000, 124: 31-48. PMID: 10943115, DOI: 10.1016/s0079-6123(00)24006-5.Peer-Reviewed Original ResearchAge FactorsAnimalsAtaxiaCell SizeCerebellumExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsIsoenzymesMiceMice, Neurologic MutantsMicroscopy, ElectronNerve FibersOrgan Culture TechniquesPhospholipase C betaPurkinje CellsRNA, MessengerSignal TransductionSynapsesType C Phospholipases