Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
Kano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Simon M, Wu D. Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15724-15729. PMID: 9861037, PMCID: PMC28111, DOI: 10.1073/pnas.95.26.15724.Peer-Reviewed Original ResearchConceptsCF synapse eliminationSynapse eliminationType 1 metabotropic glutamate receptorFiber synapse eliminationMultiple CF innervationMetabotropic glutamate receptorsPurkinje cell synapsesCF innervationCell synapsesGlutamate receptorsCaudal cerebellumCerebellar vermisRostral portionClimbing fibresRostral cerebellumCerebellar histologyPurkinje cellsSynapse formationMutant miceLocomotor ataxiaBasic electrophysiologyPhospholipase C isoformsPhospholipase Cβ4CerebellumDevelopmental elimination