Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction*
Tang L, Deng N, Wang L, Dai J, Wang Z, Jiang X, Li S, Li L, Sheng Q, Wu D, Li L, Zeng R. Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction*. Molecular & Cellular Proteomics 2007, 6: 1952-1967. PMID: 17693683, DOI: 10.1074/mcp.m700120-mcp200.Peer-Reviewed Original ResearchConceptsCanonical WntDifferential phosphoproteinsWnt3a stimulationMultiple post-translational modificationsCanonical Wnt signal transductionWnt signal transductionUnique phosphorylation sitesPost-translational modificationsInteraction network analysisStable isotopic formsCanonical Wnt signalingReporter gene assayInhibitor of WntPhosphorylation networksNovel phosphoproteinsExtracellular stimuliPhosphoproteome profilingPhosphorylation sitesSignaling networksPhosphorylation regulationProtein phosphorylationSignal transductionPhosphorylation changesRNA interferenceDownstream effectors