2024
LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments
Tang W, Luan Y, Yuan Q, Li A, Chen S, Menacherry S, Young L, Wu D. LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments. Nature Communications 2024, 15: 3068. PMID: 38594269, PMCID: PMC11004178, DOI: 10.1038/s41467-024-47262-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDietFatty AcidsFatty Acids, Omega-3Fatty Acids, UnsaturatedHumansMiceReceptors, LDLConceptsLDL receptor-related protein 5Intracellular compartmentsPolyunsaturated fatty acidsProtein 5Ligand-binding repeatsBiologically important mechanismsAssociated with human healthImport mechanismExtracellular trap formationInhibit mTORC1Cell typesFatty acidsTrap formationN-3 polyunsaturated fatty acidsCompartmentProtect miceLDLAMyocardial injuryHomologyIschemia-reperfusionMTORC1LysosomesLRP6Human healthFATP2
2001
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao J, Wang J, Liu B, Pan W, Farr G, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway. Molecular Cell 2001, 7: 801-809. PMID: 11336703, DOI: 10.1016/s1097-2765(01)00224-6.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsAxin ProteinCalcium-Calmodulin-Dependent Protein KinasesCOS CellsGene ExpressionGlycogen Synthase Kinase 3LDL-Receptor Related ProteinsLow Density Lipoprotein Receptor-Related Protein-5MammalsMiceMolecular Sequence DataMutagenesisProtein BindingProtein Structure, TertiaryProteinsProto-Oncogene ProteinsReceptors, LDLRepressor ProteinsSignal TransductionWnt ProteinsZebrafish Proteins