Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13
Mao J, Xie W, Yuan H, Simon M, Mano H, Wu D. Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13. The EMBO Journal 1998, 17: 5638-5646. PMID: 9755164, PMCID: PMC1170892, DOI: 10.1093/emboj/17.19.5638.Peer-Reviewed Original ResearchConceptsNon-receptor tyrosine kinase familySerum response factorExpression of Galpha12SRF activationRho-independent pathwayThrombin effectTyrosine kinase familyActivation of SRFNon-receptor tyrosine kinaseG12/13 proteinsRho-dependent pathwayInvolvement of RhoTec kinasesActive alpha subunitG12 familyActivationTransient transfection systemTyrosine kinaseAlpha subunitCellsNIH 3T3 cellsKinase-deficient mutantKinaseRegulation of Rho