G Protein-Coupled Signal Transduction Pathways for Interleukin-8
Wu D, LaRosa G, Simon M. G Protein-Coupled Signal Transduction Pathways for Interleukin-8. Science 1993, 261: 101-103. PMID: 8316840, DOI: 10.1126/science.8316840.Peer-Reviewed Original ResearchConceptsIL-8 receptorsInterleukin-8Free beta gamma subunitsPertussis toxin-sensitive G proteinToxin-sensitive G proteinIL-8 actsPhospholipase CSpecific heterotrimeric G proteinsAnti-inflammatory agentsG alpha 15G proteinsG alpha 11G alpha qG alpha 16G protein GiBeta 2 isoformG alpha 14Inflammatory responseAlpha 14Beta gamma subunitsProtein GiAlpha 11Alpha qMajor mediatorAlpha 15