2013
PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice
Li H, Park D, Abdul-Muneer P, Xu B, Wang H, Xing B, Wu D, Li S. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience 2013, 253: 89-99. PMID: 24012746, PMCID: PMC9529370, DOI: 10.1016/j.neuroscience.2013.08.051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCD3 ComplexClass Ib Phosphatidylinositol 3-KinaseDioxolesDisease Models, AnimalEctodysplasinsEncephalomyelitis, Autoimmune, ExperimentalEnzyme InhibitorsGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNeurofilament ProteinsPeptide FragmentsPhosphoinositide-3 Kinase InhibitorsSerotoninSeverity of Illness IndexSpinal CordThiazolidinedionesTime FactorsConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisEAE miceSpinal cordExperimental autoimmune encephalomyelitis (EAE) miceAutoimmune CNS inflammationLumbar spinal cordNumber of axonsCNS inflammationAutoimmune encephalomyelitisSystemic treatmentClinical symptomsPI3Kγ inhibitionInflammatory cellsAxon numberClinical signsInflammatory responseInflammatory reactionKnockout miceFiber tractsMicePI3Kγ inhibitorsCordSymptomsPI3Kγ
2012
P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs
Naikawadi R, Cheng N, Vogel S, Wu D, Malik A, Ye R. P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs. The FASEB Journal 2012, 26: 842.10-842.10. DOI: 10.1096/fasebj.26.1_supplement.842.10.Peer-Reviewed Original ResearchHuman lung microvascular endothelial cellsCultured human lung microvascular endothelial cellsEndothelial cellsLung vascular injuryLung microvascular endothelial cellsPotential therapeutic targetNeutrophil transendothelial migrationEndothelial barrier disruptionMicrovascular endothelial cellsICAM-1 inductionP-Rex1G protein-coupled receptorsReactive oxygen species productionNeutrophil infiltrationProtein-coupled receptorsBarrier disruptionIntercellular gap formationVascular injurySmall interference RNAInflammatory tissueOxygen species productionVascular permeabilityPI3K dependent mannerKnockout miceTherapeutic target
2010
P‐Rex1 regulates lung microvascular permeability
Naikawadi R, Cheng N, Wu D, Ye R. P‐Rex1 regulates lung microvascular permeability. The FASEB Journal 2010, 24: lb554-lb554. DOI: 10.1096/fasebj.24.1_supplement.lb554.Peer-Reviewed Original ResearchAcute lung injuryLung microvascular permeabilityPolymorphonuclear leukocytesLung injuryEndothelial cellsP-Rex1 expressionMicrovascular permeabilityLung microvascular endothelial cellsGram-negative bacterial infectionsTNF-alpha contributesWild-type miceMicrovascular endothelial cellsEndothelial barrier permeabilityP-Rex1Endothelial cell signalingBacterial clearanceTNF-alphaReactive oxygen species generationBarrier permeabilityType miceMajor cytokineKnockout miceBacterial infectionsSepticemic infectionUncontrolled activation
2001
Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout Mice
Romoser V, Graves T, Wu D, Jiang H, Hinkle P. Calcium Responses to Thyrotropin-Releasing Hormone, Gonadotropin-Releasing Hormone and Somatostatin in Phospholipase Cβ3 Knockout Mice. Endocrinology 2001, 15: 125-135. PMID: 11145744, DOI: 10.1210/mend.15.1.0588.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaBlotting, WesternCalciumCells, CulturedFemaleFluorescent Antibody TechniqueGonadotropin-Releasing HormoneIsoenzymesMaleMiceMice, KnockoutMicroscopy, FluorescenceMuscle, Smooth, VascularPituitary GlandSignal TransductionSomatostatinThyrotropin-Releasing HormoneType C PhospholipasesConceptsWild-type miceKnockout micePituitary cellsSmooth muscle cellsCalcium responseIntracellular calciumMuscle cellsAortic smooth muscle cellsThyrotropin-Releasing HormoneCalcium-mobilizing actionGonadotropin-Releasing HormoneInhibited influxMicroM TRHExtracellular calciumSomatostatinPituitary tissueKnockout animalsMiceHormoneSignal pathwayPLCbeta1Phospholipase CbetaPLCbeta3CalciumGalphaq/11