1996
Selective G Protein Coupling by C-C Chemokine Receptors (∗)
Kuang Y, Wu Y, Jiang H, Wu D. Selective G Protein Coupling by C-C Chemokine Receptors (∗). Journal Of Biological Chemistry 1996, 271: 3975-3978. PMID: 8626727, DOI: 10.1074/jbc.271.8.3975.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvian ProteinsCell LineChemokine CCL2Chlorocebus aethiopsCloning, MolecularDNA PrimersDNA-Binding ProteinsGTP-Binding ProteinsHumansKineticsMonocytesPertussis ToxinPolymerase Chain ReactionReceptors, CCR2Receptors, ChemokineReceptors, CytokineRecombinant ProteinsTransfectionType C PhospholipasesVirulence Factors, BordetellaZinc FingersConceptsC chemokine receptor 1C chemokine receptorChemokine receptorsBroad spectrum anti-inflammatory drugsPertussis toxin-sensitive mannerChemokine receptor 1MCP-1 receptorAnti-inflammatory drugsG protein coupling specificityToxin-sensitive mannerGq classG protein couplingAccumulation of inositolPhospholipase CC chemokinesT cellsInflammatory reactionCotransfected COS-7 cellsGi proteinsReceptor 1Major mediatorC-terminal intracellular domainG beta gammaProtein couplingReceptors
1995
Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗)
Wu D, Kuang Y, Wu Y, Jiang H. Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗). Journal Of Biological Chemistry 1995, 270: 16008-16010. PMID: 7608160, DOI: 10.1074/jbc.270.27.16008.Peer-Reviewed Original ResearchConceptsG alpha 16G alpha 15G alpha 11G alpha qG alpha 14Alpha 14Alpha 11Alpha qPhospholipase CAlpha 15G beta gammaAR agonist isoprenalineAlpha 16Norepinephrine-induced increaseNorepinephrine-induced activationG proteinsActivation of PLCCOS-7 cellsReceptor-mediated activationAccumulation of inositolConcentration-dependent mannerAntagonist propranololCotransfected cellsΒ2-adrenergic receptorAgonist isoprenaline