1995
Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗)
Wu D, Kuang Y, Wu Y, Jiang H. Selective Coupling of β2-Adrenergic Receptor to Hematopoietic-specific G Proteins (∗). Journal Of Biological Chemistry 1995, 270: 16008-16010. PMID: 7608160, DOI: 10.1074/jbc.270.27.16008.Peer-Reviewed Original ResearchConceptsG alpha 16G alpha 15G alpha 11G alpha qG alpha 14Alpha 14Alpha 11Alpha qPhospholipase CAlpha 15G beta gammaAR agonist isoprenalineAlpha 16Norepinephrine-induced increaseNorepinephrine-induced activationG proteinsActivation of PLCCOS-7 cellsReceptor-mediated activationAccumulation of inositolConcentration-dependent mannerAntagonist propranololCotransfected cellsΒ2-adrenergic receptorAgonist isoprenaline
1994
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.
Jiang H, Wu D, Simon M. Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. Journal Of Biological Chemistry 1994, 269: 7593-7596. PMID: 8125982, DOI: 10.1016/s0021-9258(17)37328-3.Peer-Reviewed Original ResearchConceptsPhospholipase C beta 4Beta 4PLC-beta 4C beta 4Gq classBeta 2 gamma 2Beta 1 gamma 2G alpha 15Alpha subunitG alpha 11G alpha qG alpha 16Gamma 2G beta gamma subunitsG alpha 14G beta 1 gamma 2Alpha 14Beta 1 gamma 1Beta gamma subunitsBeta 1 isoformAlpha 11Alpha qAlpha 15Heterotrimeric GTPGamma subunits
1993
G Protein-Coupled Signal Transduction Pathways for Interleukin-8
Wu D, LaRosa G, Simon M. G Protein-Coupled Signal Transduction Pathways for Interleukin-8. Science 1993, 261: 101-103. PMID: 8316840, DOI: 10.1126/science.8316840.Peer-Reviewed Original ResearchConceptsIL-8 receptorsInterleukin-8Free beta gamma subunitsPertussis toxin-sensitive G proteinToxin-sensitive G proteinIL-8 actsPhospholipase CSpecific heterotrimeric G proteinsAnti-inflammatory agentsG alpha 15G proteinsG alpha 11G alpha qG alpha 16G protein GiBeta 2 isoformG alpha 14Inflammatory responseAlpha 14Beta gamma subunitsProtein GiAlpha 11Alpha qMajor mediatorAlpha 15