In vivo self-assembled small RNAs as a new generation of RNAi therapeutics
Fu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu S, Wu D, Zen K, Li J, Yan C, Zhang C, Chen X. In vivo self-assembled small RNAs as a new generation of RNAi therapeutics. Cell Research 2021, 31: 631-648. PMID: 33782530, PMCID: PMC8169669, DOI: 10.1038/s41422-021-00491-z.Peer-Reviewed Original ResearchConceptsRNAi therapeuticsRNAi therapyVivo siRNA deliveryEGFR/KRASSiRNA deliveryVivo deliverySynthetic siRNAsLung cancerHost liverPotent target geneSecretory exosomesTherapeutic valueCircuit moduleArtificial vehiclesGenetic circuitsTherapyMultiple tissuesSiRNAsCritical targetPrinciple strategyTissueSpecific tissuesTherapeuticsDeliveryExosomes