2014
CD4 T cell activation by B cells in human Leishmania (Viannia)infection
Rodriguez-Pinto D, Saravia NG, McMahon-Pratt D. CD4 T cell activation by B cells in human Leishmania (Viannia)infection. BMC Infectious Diseases 2014, 14: 108. PMID: 24568275, PMCID: PMC3937821, DOI: 10.1186/1471-2334-14-108.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiotinB-LymphocytesCD4-Positive T-LymphocytesColombiaFemaleFlow CytometryFluorescein-5-isothiocyanateGene Expression RegulationHumansImmunoglobulin MInterferon-gammaInterleukin-6Leishmania braziliensisLeishmaniasis, CutaneousLeukocytes, MononuclearLymphocyte ActivationMaleMiddle AgedOvalbuminTumor Necrosis Factor-alphaYoung AdultConceptsCD4 T cellsCutaneous leishmaniasis patientsT cellsB cellsLeishmaniasis patientsT cell activationLeishmania antigenImmune responseCell activationT-cell activation parametersSpecific CD4 T cellsEffective adaptive immune responseCD4 T cell activationB-cell activation markersCultures of PBMCUpregulation of CD86Cell activation markersCostimulatory molecule CD86Activation markers CD25Adaptive immune responsesHuman cutaneous leishmaniasisPurified B cellsT cell culturesHuman B cell linesHuman B cells
2000
Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina
Segura E, Juan N, Piquin A, Cuba Cuba C, Abramo Orrego L, McMahon-Pratt D, Montamat E, Momen H, Grimaldi Jr. G. Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina. Parasitology Research 2000, 86: 504-508. PMID: 10894479, DOI: 10.1007/s004360050702.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsArgentinaCricetinaeDisease OutbreaksFemaleHumansLeishmaniaLeishmania braziliensisLeishmaniasis, MucocutaneousMaleMesocricetusRadioimmunoassay
1996
T-Cell Responsiveness of American Cutaneous Leishmaniasis Patients to PurifiedLeishmania pifanoiAmastigote Antigens andLeishmania braziliensisPromastigote Antigens: Immunologic Patterns Associated with Cure
Coutinho S, Oliveira M, Da-Cruz A, De Luca P, Mendonça S, Bertho A, Soong L, McMahon-Pratt D. T-Cell Responsiveness of American Cutaneous Leishmaniasis Patients to PurifiedLeishmania pifanoiAmastigote Antigens andLeishmania braziliensisPromastigote Antigens: Immunologic Patterns Associated with Cure. Experimental Parasitology 1996, 84: 144-155. PMID: 8932764, DOI: 10.1006/expr.1996.0100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, ProtozoanAntimonyAntiprotozoal AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCytokinesFemaleHumansInterferon-gammaInterleukin-2Interleukin-4LeishmaniaLeishmania braziliensisLeishmaniasis, CutaneousLymphocyte ActivationMaleMeglumineMeglumine AntimoniateOrganometallic CompoundsT-LymphocytesConceptsT cell responsesEnd of therapyBeneficial T cell responsesCell responsesCytokine productionProliferative responseAmerican cutaneous leishmaniasis patientsType 1 cytokine productionType 2 cytokine productionPeripheral blood mononuclear cellsCutaneous leishmaniasis patientsType 1 cytokinesLymphocyte proliferative responsesBlood mononuclear cellsLow proliferative responseT cell responsivenessMixed type 1T cell stimulationAmerican cutaneous leishmaniasisImmunologic patternActive diseaseReactive CD4Amastigote antigensLeishmaniasis patientsMononuclear cells
1992
Cutaneous leishmaniasis in western Venezuela caused by infection with Leishmania venezuelensis and L. braziliensis variants
Bonfante-Garrido R, Meléndez E, Barroeta S, de Alejos M, Momen H, Cupolillo E, McMahon-Pratt D, Grimaldi G. Cutaneous leishmaniasis in western Venezuela caused by infection with Leishmania venezuelensis and L. braziliensis variants. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1992, 86: 141-148. PMID: 1440772, DOI: 10.1016/0035-9203(92)90544-m.Peer-Reviewed Original ResearchConceptsL. braziliensisEndemic regionsSame endemic regionLeishmania venezuelensisL. venezuelensisSpecific monoclonal antibodiesCutaneous leishmaniasisPositive culturesEpidemiological studiesInfected donkeysHuman casesMonoclonal antibodiesDomestic reservoirBraziliensisL. guyanensisVenezuelensisState of LaraIsoenzyme electrophoresisReference strainsLoss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex
McMahon-Pratt D, Traub-Cseko Y, Lohman K, Rogers D, Beverley S. Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex. Molecular And Biochemical Parasitology 1992, 50: 151-160. PMID: 1542309, DOI: 10.1016/0166-6851(92)90252-f.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionBlotting, SouthernBlotting, WesternKaryotypingLeishmaniaLeishmania braziliensisMembrane GlycoproteinsMultigene FamilyProtozoan ProteinsConceptsGP46/MGene familyGlycoprotein gene familyMolecular karyotype analysisBraziliensis complexLeishmania braziliensis complexSpeciation eventsTrypanosomatid speciesPhylogenetic analysisCrithidia fasciculataLeishmania tarentolaeDevelopmental cycleWestern blot analysisLeishmania mexicana complexMembrane glycoproteinsKaryotype analysisBlot analysisL. braziliensis complexProtein expressionPolyclonal antiserumMexicana complexSpeciesL. panamensisLeishmania majorL. braziliensis
1991
Characterization and classification of leishmanial parasites from humans, wild mammals, and sand flies in the Amazon region of Brazil.
Grimaldi G, Momen H, Naiff R, McMahon-Pratt D, Barrett T. Characterization and classification of leishmanial parasites from humans, wild mammals, and sand flies in the Amazon region of Brazil. American Journal Of Tropical Medicine And Hygiene 1991, 44: 645-61. PMID: 1858968, DOI: 10.4269/ajtmh.1991.44.645.Peer-Reviewed Original ResearchLeishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease.
Barral A, Pedral-Sampaio D, Grimaldi G, Momen H, McMahon-Pratt D, de Jesus A, Almeida R, Badaro R, Barral-Netto M, Carvalho E, Johnson W. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. American Journal Of Tropical Medicine And Hygiene 1991, 44: 536-46. PMID: 2063957, DOI: 10.4269/ajtmh.1991.44.536.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrazilHumansLeishmaniaLeishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousLeishmaniasis, VisceralConceptsMucocutaneous leishmaniasisCutaneous leishmaniasisClinical presentationVisceral leishmaniasisCases of CLMonoclonal antibodiesLeishmania amazonensisCases of DCLL. amazonensis infectionDifferent clinical presentationsDifferent clinical formsDifferent Leishmania speciesAmazonensis infectionClinical groundsIndistinguishable clinical presentationDermal leishmaniasisSpecific monoclonal antibodiesClinical formsClinical diseaseLeishmanial diseaseL. chagasiWide spectrumLeishmania referenceLeishmaniasisL. amazonensis
1989
Extracellular Amastigote‐Like Forms of Leishmania panamensis and L. braziliensis. II. Stage‐ and Species‐Specific Monoclonal Antibodies
EPERON S, McMAHON‐PRATT D. Extracellular Amastigote‐Like Forms of Leishmania panamensis and L. braziliensis. II. Stage‐ and Species‐Specific Monoclonal Antibodies. Journal Of Eukaryotic Microbiology 1989, 36: 510-518. PMID: 2478699, DOI: 10.1111/j.1550-7408.1989.tb01087.x.Peer-Reviewed Original ResearchI. Extracellular Cultivation and Morphological Characterization of Amastigote‐Like Forms of Leishmania panamensis and L. braziliensis
EPERON S, McMAHON‐PRATT D. I. Extracellular Cultivation and Morphological Characterization of Amastigote‐Like Forms of Leishmania panamensis and L. braziliensis. Journal Of Eukaryotic Microbiology 1989, 36: 502-510. PMID: 2810145, DOI: 10.1111/j.1550-7408.1989.tb01086.x.Peer-Reviewed Original ResearchAnimalsCell LineCulture MediaLeishmaniaLeishmania braziliensisMacrophagesMicroscopy, ElectronTemperature
1988
The identification of membrane glycoconjugates in Leishmania species.
Jaffe C, McMahon-Pratt D. The identification of membrane glycoconjugates in Leishmania species. Journal Of Parasitology 1988, 74: 548-61. PMID: 3397816, DOI: 10.2307/3282170.Peer-Reviewed Original Research
1987
Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies.
Grimaldi G, David J, McMahon-Pratt D. Identification and distribution of New World Leishmania species characterized by serodeme analysis using monoclonal antibodies. American Journal Of Tropical Medicine And Hygiene 1987, 36: 270-87. PMID: 3826486, DOI: 10.4269/ajtmh.1987.36.270.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalBrazilCentral AmericaHumansLeishmaniaLeishmania braziliensisLeishmania donovaniLeishmania mexicanaLeishmania tropicaSouth AmericaConceptsWide geographic distributionWide geographical distributionWild reservoir hostsSubspecies levelNew World LeishmaniaMolecular markersGeographic distributionL. mexicana complexL. braziliensis complexSpecific monoclonal antibodiesGeographical distributionL. donovani chagasiL. mexicanaMexicana complexReservoir hostsMonoclonal antibodiesParasite identificationBraziliensis complexL. donovani complexMexicanaStocks of LeishmaniaL. braziliensisIsolatesComplexesLeishmaniaLeishmaniasis in Brazil: XXIII. The identification of Leishmania braziliensis braziliensis in wild-caught neotropical sandflies using monoclonal antibodies
Shaw J, Lainson R, Ryan L, Braga R, McMahon-Pratt D, David J. Leishmaniasis in Brazil: XXIII. The identification of Leishmania braziliensis braziliensis in wild-caught neotropical sandflies using monoclonal antibodies. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1987, 81: 69-72. PMID: 3445325, DOI: 10.1016/0035-9203(87)90287-2.Peer-Reviewed Original Research
1985
Brazilian Leishmania stocks phenotypically similar to Leishmania major.
Momen H, Pacheco R, Jaffe C, Grimaldi G, Marzochi M, McMahon-Pratt D. Brazilian Leishmania stocks phenotypically similar to Leishmania major. American Journal Of Tropical Medicine And Hygiene 1985, 34: 1076-84. PMID: 3834794, DOI: 10.4269/ajtmh.1985.34.1076.Peer-Reviewed Original ResearchConceptsEnzyme profilesEnzyme electrophoresisL. mexicanaRestriction enzyme profilesL. donovani speciesIndirect radioimmuneNew World LeishmaniaL. braziliensisSchizodeme analysisL. majorMonoclonal antibodiesCutaneous speciesReference strainsSpeciesDifferent geographic areasMexicanaL. donovaniElectrophoresisLeishmaniaLarge panelSubspeciesBspRIMspIBraziliensisGeographic areas