Leishmania amazonensis:The Asian Rhesus Macaques (Macaca mulatta) as an Experimental Model for Study of Cutaneous Leishmaniasis
Amaral V, Ransatto V, Conceição-Silva F, Molinaro E, Ferreira V, Coutinho S, McMahon-Pratt D, Grimaldi G. Leishmania amazonensis:The Asian Rhesus Macaques (Macaca mulatta) as an Experimental Model for Study of Cutaneous Leishmaniasis. Experimental Parasitology 1996, 82: 34-44. PMID: 8617329, DOI: 10.1006/expr.1996.0005.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisRhesus macaquesActive infectionPrimate modelT cellsPeripheral T-cell subpopulationsType hypersensitivity responseLevels of IgMT cell subpopulationsNonhuman primate modelCourse of infectionAsian rhesus macaquesLeishmanial antigensHomologous infectionMononuclear infiltrateProtective immunityHypersensitivity responseIgG antibodiesPathologic analysisLeishmanial infectionPlasma cellsSkin lesionsProliferative responseLesion sizeInitial infection