2009
Regeneration and Repair
Friedman RS, Krause DS. Regeneration and Repair. Annals Of The New York Academy Of Sciences 2009, 1172: 88-94. PMID: 19735242, DOI: 10.1111/j.1749-6632.2009.04411.x.Peer-Reviewed Original Research
2008
Bone Marrow–derived Cells and Stem Cells in Lung Repair
Krause DS. Bone Marrow–derived Cells and Stem Cells in Lung Repair. Annals Of The American Thoracic Society 2008, 5: 323-327. PMID: 18403327, PMCID: PMC2645242, DOI: 10.1513/pats.200712-169dr.Peer-Reviewed Original ResearchConceptsMarrow-derived epithelial cellsEpithelial cellsBM cellsTissue injuryBone marrow-derived cellsBM-derived cellsMarrow-derived cellsPotential clinical utilityBronchiolar epithelial cellsType II pneumocytesLung damageTracheal epithelial cellsLung repairClinical utilityGI tractBone marrowTissue damagePeer-reviewed studiesNonhematopoietic cell typesBeneficial effectsPotential mechanismsTissue repairLungInjuryTissue microenvironment
2006
Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells
Tolar J, O'Shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood 2006, 107: 4182-4188. PMID: 16410448, PMCID: PMC1895284, DOI: 10.1182/blood-2005-08-3289.Peer-Reviewed Original ResearchConceptsMultipotent adult progenitor cellsAdult progenitor cellsB cell-deficient miceMajor histocompatibility complex antigensT cell alloresponsesProgenitor cellsIntra-arterial injectionIntra-arterial deliveryHistocompatibility complex antigensMHC class INK depletionAllogeneic marrowNK cellsNK cytolysisMajor uptake siteWidespread biodistributionHost irradiationT cellsIntravenous injectionComplex antigensImmunohistochemical analysisB cellsUptake sitesHost factorsClass I
2004
Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury
Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury. Circulation 2004, 110: 3300-3305. PMID: 15533866, DOI: 10.1161/01.cir.0000147780.30124.cf.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzylaminesBone Marrow CellsBone Marrow TransplantationCell LineageCell MovementChemokine CXCL12Chemokines, CXCCyclamsFemaleGene Expression ProfilingGene Expression RegulationGenetic TherapyHeterocyclic CompoundsIntercellular Adhesion Molecule-1Matrix Metalloproteinase 9MiceMice, Inbred NODMice, SCIDMyocardial InfarctionMyocardiumReceptors, CXCR4Recombinant Fusion ProteinsStem Cell TransplantationStem CellsTransduction, GeneticVascular Cell Adhesion Molecule-1Vascular Endothelial Growth Factor AConceptsBone marrow-derived cellsStromal cell-derived factor-1alphaMyocardial infarctionBMDC recruitmentAdhesion molecule-1Molecule-1Recruitment of BMDCsInfarcted heartSerum SDF-1 levelsVascular cell adhesion molecule-1Intercellular adhesion molecule-1Stromal cell-derived factor-1αCell adhesion molecule-1Administration of AMD3100SDF-1/CXCR4 interactionMarrow-derived cellsSDF-1 levelsAbsence of MIVascular endothelial growth factorMatrix metalloproteinase-9Sham-operated controlsSDF-1 mRNAEndothelial growth factorAbsence of injuryQuantitative polymerase chain reactionPlasticity of Bone Marrow–Derived Stem Cells
Grove JE, Bruscia E, Krause DS. Plasticity of Bone Marrow–Derived Stem Cells. Stem Cells 2004, 22: 487-500. PMID: 15277695, DOI: 10.1634/stemcells.22-4-487.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsCell DifferentiationHematopoietic Stem CellsHumansStem Cell TransplantationStem CellsTransplantation, HeterologousConceptsBone marrow stem cellsHematopoietic stem cellsStem cellsCell plasticityMesenchymal stem cellsStem cell plasticityGene expression profilesAdult stem cellsAdult bone marrow cellsMature lineagesAdult bone marrow stem cellsTissue of originExpression profilesMature cellsMarrow stem cellsBone marrow cellsNonhematopoietic tissuesMature phenotypePlasticityMarrow cellsCellsLineagesBone marrowPhenotypeTissue
2003
Plasticity of marrow-derived stem cells
Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003, 102: 3483-3493. PMID: 12893756, DOI: 10.1182/blood-2003-05-1664.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsCell DifferentiationCell MovementHematopoietic Stem CellsHumansMultipotent Stem CellsOrgan SpecificityStem Cell TransplantationStem CellsStromal CellsConceptsHematopoietic stem cellsStem cellsAdult stem cell plasticityMesenchymal stem cellsStem cell plasticityBone marrowMature blood cellsEndothelial cell progenitorsAdult bone marrowBone marrow subpopulationsMultiple mesenchymal tissuesCell plasticityMarrow-derived stem cellsCell progenitorsMarrow subpopulationsMultiple tissuesMature cellsConditions differentiationNeural cellsDifferentiationEpithelial cellsNonhematopoietic cellsTissue injuryGastrointestinal tractSkeletal muscleComment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells"
Theise ND, Krause DS, Sharkis S. Comment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells". Science 2003, 299: 1317a-1317. PMID: 12610282, DOI: 10.1126/science.1078412.Peer-Reviewed Original Research
2002
Bone marrow to liver: the blood of Prometheus
Theise ND, Krause DS. Bone marrow to liver: the blood of Prometheus. Seminars In Cell And Developmental Biology 2002, 13: 411-417. PMID: 12468241, DOI: 10.1016/s1084952102001283.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile DuctsBone Marrow CellsCell DifferentiationGraft SurvivalHumansLiverLiver RegenerationStem Cell TransplantationStem CellsRadiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrow
Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrow. Experimental Hematology 2002, 30: 1333-1338. PMID: 12423687, DOI: 10.1016/s0301-472x(02)00931-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBone Marrow TransplantationCell DifferentiationCell LineageEpithelial CellsFemaleGraft SurvivalIn Situ Hybridization, FluorescenceLungMaleMiceModels, AnimalPulmonary AlveoliPulmonary Surfactant-Associated Protein BRadiation ChimeraRadiation PneumonitisRNA, MessengerStem Cell TransplantationStem CellsY ChromosomeConceptsBone marrow transplantType II pneumocytesBone marrow cellsFemale miceLethal irradiationAge-matched male donorsWhole bone marrow transplantsMarrow cellsDay 5 posttransplantAlveolar lining cellsFluorescence-activated cell sorterSevere injury modelType I cellsAlveolar breakdownEntire alveoliRadiation pneumonitisB messenger RNAHistologic evidenceMarrow transplantAcute injuryMonth 2Injury modelLung tissueLining cellsBone marrow