2013
Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia
Krause DS, Crispino JD. Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia. Clinical Cancer Research 2013, 19: 6084-6088. PMID: 23963861, PMCID: PMC3836832, DOI: 10.1158/1078-0432.ccr-12-2604.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute megakaryocytic leukemiaAcute promyelocytic leukemiaDifferentiation therapyForms of AMLSpecific hematologic malignanciesAbnormal hematopoietic cellsTrans retinoic acidPolyploidy inducersTumor burdenMyelodysplastic syndromeHematologic malignanciesEffective therapyInduction of polyploidizationMyeloid leukemiaClinical studiesPromyelocytic leukemiaMegakaryocytic leukemiaPrimary myelofibrosisTherapyLeukemiaDifferentiation of megakaryocytesRetinoic acidMalignancySuch agents
1998
Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.
Lawson ND, Krause DS, Berliner N. Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines. Experimental Hematology 1998, 26: 1178-85. PMID: 9808058.Peer-Reviewed Original ResearchConceptsNeutrophil differentiationDominant-negative retinoic acid receptor alphaCell linesNormal neutrophil differentiationRetinoic acid receptor alphaCD11b/CD18Macrophage colony-stimulating factorDownregulation of CD34Granulocyte/macrophage colony-stimulating factorTrans retinoic acidAcid receptor alphaColony-stimulating factorNeutrophil gelatinaseGranulocytic differentiation programReceptor alphaSerum-free mediumAppropriate cytokinesMyeloid lineageRetinoic acidInduces expressionLeukemic myelopoiesisHL60MyelopoiesisNeutrophilic differentiationDifferentiation program