2021
Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury
Ciechanowicz AK, Sielatycka K, Cymer M, Skoda M, Suszyńska M, Bujko K, Ratajczak MZ, Krause DS, Kucia M. Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury. Cells 2021, 10: 1570. PMID: 34206516, PMCID: PMC8303224, DOI: 10.3390/cells10071570.Peer-Reviewed Original ResearchConceptsBronchioalveolar stem cellsOrganoid assaysAT2 cellsStem cellsH2B-GFP fusion proteinLung epithelial progenitor cellsProgenitor cellsEmbryonic-like stem cellsSurfactant protein CSmall embryonic-like stem cellsEpithelial progenitor cellsLung injuryNonhematopoietic stem cellsFusion proteinAlveolar type 2 cellsPhysiological potentialProgenitor activityBleomycin-Induced Lung InjuryH2B-GFP miceWT recipient miceRegenerative functionSPC promoterType 2 cellsVSELsReporter mice
2013
Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the Lung
Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the Lung. Stem Cells 2013, 31: 2759-2766. PMID: 23681901, PMCID: PMC4536826, DOI: 10.1002/stem.1413.Peer-Reviewed Original ResearchConceptsEpithelial cellsSmall embryonic-like stem cellsLung epithelial cellsEmbryonic-like stem cellsStem/progenitor cellsStem cellsDonor miceHematopoietic stem/progenitor cellsBM cellsAdult BMBone marrowSmall embryonicNonhematopoietic cellsProgenitor cellsBroad differentiation potentialVSELsEngraftmentLungHigh rateNumerous reportsAdult stem cellsDifferentiation potentialCellsFirst reportReportVery small embryonic‐like cells: Biology and function of these potential endogenous pluripotent stem cells in adult tissues
Kassmer SH, Krause DS. Very small embryonic‐like cells: Biology and function of these potential endogenous pluripotent stem cells in adult tissues. Molecular Reproduction And Development 2013, 80: 677-690. PMID: 23440892, PMCID: PMC3740022, DOI: 10.1002/mrd.22168.Peer-Reviewed Original ResearchConceptsEmbryonic-like cellsSmall embryonic-like cellsAdult tissuesCell typesPrimordial germ cellsGerm layer lineagesMarkers of pluripotentSingle-cell levelPluripotent stem cellsCell cycle inhibitory genesSimilar cell typesMurine bone marrowPluripotency genesMurine VSELsNon-hematopoietic cellsCell cycleGerm cellsInhibitory genesStress conditionsStem cellsDifferent phenotypesGenesRegenerative medicineVSELsCells