Multilineage gene expression precedes commitment in the hemopoietic system.
Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes & Development 1997, 11: 774-785. PMID: 9087431, DOI: 10.1101/gad.11.6.774.Peer-Reviewed Original ResearchConceptsGene expression programsMultilineage gene expressionLineage specificationExpression programsGene activityLocus activationMultipotential stateGene expressionCytokine receptorsHemopoietic stemGranulocytic lineageProgenitor cellsSingle-cell RT-PCRSame cellsHemopoietic systemRT-PCRExclusive commitmentCell RT-PCRCellsLineagesCoexpressionDifferentiationExpressionStemActivation