Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.
Lawson ND, Krause DS, Berliner N. Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines. Experimental Hematology 1998, 26: 1178-85. PMID: 9808058.Peer-Reviewed Original ResearchConceptsNeutrophil differentiationDominant-negative retinoic acid receptor alphaCell linesNormal neutrophil differentiationRetinoic acid receptor alphaCD11b/CD18Macrophage colony-stimulating factorDownregulation of CD34Granulocyte/macrophage colony-stimulating factorTrans retinoic acidAcid receptor alphaColony-stimulating factorNeutrophil gelatinaseGranulocytic differentiation programReceptor alphaSerum-free mediumAppropriate cytokinesMyeloid lineageRetinoic acidInduces expressionLeukemic myelopoiesisHL60MyelopoiesisNeutrophilic differentiationDifferentiation program