2022
Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis
Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.Peer-Reviewed Original ResearchConceptsHeme oxygenase-1Cystic fibrosisOxygenase-1Myeloid differentiation factor 88Neutrophilic pulmonary inflammationChronic airway infectionDifferentiation factor 88HO-1 levelsDisease mouse modelPseudomonas aeruginosaRecruitment of monocytesResolution of inflammationMonocytes/macrophagesTreatment of CFConditional knockout miceMechanism of actionLung neutrophiliaNeutrophilic inflammationLung inflammationAirway infectionPulmonary diseasePulmonary inflammationFactor 88Lung damageProinflammatory cytokines
2015
Regulation of chronic lung inflammation to house dust mite allergen by Wnt antagonist (CAM1P.144)
Bothwell A, Chae W, Teixeira A, Chan P, Hao L, Rothlin C, Krause D. Regulation of chronic lung inflammation to house dust mite allergen by Wnt antagonist (CAM1P.144). The Journal Of Immunology 2015, 194: 48.1-48.1. DOI: 10.4049/jimmunol.194.supp.48.1.Peer-Reviewed Original ResearchLeukocyte-platelet aggregatesCD4 T cellsAllergen challengeDkk-1D miceWildtype miceT cellsType 2 immune responsesHouse dust mite allergenWnt antagonistsLigand 1 expressionMediastinal lymph nodesType 2 cytokinesChronic lung inflammationInfiltration of leukocytesDust mite allergenAirway inflammationAllergen exposureLung inflammationLymph nodesLeukocyte infiltrationTh2 cellsCell adhesion moleculeImmune responseICAM-1