Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts
de Dios Ruiz‐Rosado J, Lee Y, Mahler N, Yi T, Robledo‐Avila F, Martinez‐Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida‐Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. The FASEB Journal 2018, 32: 6822-6832. PMID: 29906242, PMCID: PMC6219835, DOI: 10.1096/fj.201800458.Peer-Reviewed Original ResearchAngiotensin II receptor ITEVG stenosisPrevents stenosisMononuclear cellsAngiotensin II type 1 receptor antagonistReceptor IBone marrow-derived mononuclear cellsShort-term losartan treatmentType 1 receptor antagonistMarrow-derived mononuclear cellsVascular graftsShort-term administrationCongenital heart surgeryTissue-engineered vascular graftsLong-term patencyWidespread clinical useLosartan treatmentPharmacologic treatmentAcute phaseMonocyte infiltrationHeart surgeryReceptor antagonistCCR2 knockoutRecipient miceClinical trials