2024
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expression
1996
Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway
Navaratnam D, Su H, Scott S, Oberholtzer J. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway. Nature Medicine 1996, 2: 1136-1139. PMID: 8837614, DOI: 10.1038/nm1096-1136.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsCarbazolesChickensCochleaColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesDNA ReplicationEnzyme ActivationEnzyme InhibitorsGentamicinsHair Cells, AuditoryHearing Loss, SensorineuralIndolesIsoquinolinesOrgan Culture TechniquesPyrrolesRegenerationSignal TransductionSulfonamidesConceptsAuditory receptor epitheliumProtein kinase AHair cellsReplacement hair cellsReceptor epitheliumNew hair cellsProliferative responseRegenerative proliferationReceptor hair cellsKinase ASignaling pathwaysPKA inhibitorGentamicin damageCellular recoveryCyclic AMP levelsCell populationsFunctional recoveryBacterial insultPathwayProliferation markersProliferationAMP levelsCellsEpitheliumIntense sound