2020
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature 2020, 580: 524-529. PMID: 32322056, PMCID: PMC7490650, DOI: 10.1038/s41586-020-2166-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, LyArachidonic AcidCarcinogenesisCell Cycle ProteinsCell ProliferationColorectal NeoplasmsCyclooxygenase 2DinoprostoneFemaleFibroblastsHumansIntestinal MucosaIntestinesMaleMembrane ProteinsMesodermMiceNeoplastic Stem CellsOrganoidsParacrine CommunicationReceptors, Prostaglandin E, EP4 SubtypeSingle-Cell AnalysisStem Cell NicheYAP-Signaling ProteinsConceptsSingle-cell RNA-sequencing analysisTumor-initiating stem cellsRNA sequence analysisMesenchymal nicheStem cellsTumor initiationSca-1Hippo pathway effector YAPStem cell functionCell expansionPathway effector YAPMutant stem cellsEpithelial-specific ablationIntestinal stem cellsEarly tumor initiationProstaglandin E2Regenerative reprogrammingNormal epithelial stem cellsParacrine controlTumorigenic programsNiche modelsNuclear localizationTranscriptional activityYAP dephosphorylationEpithelial stem cells
2015
Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use
Sethi A, Jain D, Roland BC, Kinzel J, Gibson J, Schrader R, Hanson JA. Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use. Archives Of Pathology & Laboratory Medicine 2015, 139: 225-32. PMID: 25611105, DOI: 10.5858/arpa.2013-0594-oa.Peer-Reviewed Original ResearchConceptsHigh-power fieldMC countChronic diarrheaMast cell countsUnknown etiologyMast cellsCutoff valueMastocytic enterocolitisLeft colonBiopsy resultsClinical utilityDiscriminatory cutoff valuesCell countC-kit stainConsecutive control patientsMast cell stabilizerSpecific cutoff valuesSingle high-power fieldControl patientsConsecutive patientsNormal biopsiesCell stabilizerCharacteristic analysisStudy groupSpecial stains
2004
Benign Fibroblastic Polyps of the Colon
Eslami-Varzaneh F, Washington K, Robert ME, Kashgarian M, Goldblum JR, Jain D. Benign Fibroblastic Polyps of the Colon. The American Journal Of Surgical Pathology 2004, 28: 374-378. PMID: 15104300, DOI: 10.1097/00000478-200403000-00010.Peer-Reviewed Original ResearchConceptsMucosal polypsHyperplastic polypsInflammatory fibroid polypGastrointestinal stromal tumorsSpindle cell proliferationBland spindled cellsPanel of antibodiesSmooth muscle actinBenign fibroblastic polypsAssociated adenomasFibroid polypEndoscopic findingsStromal polypsClinicopathologic featuresStromal tumorsSparse cytoplasmic organellesImmunohistochemical findingsFibroblastic featuresNeural tumorsFocal reactivityPolyposis syndromeSpindled cellsMuscularis mucosaeSpindle cellsLamina propria
2003
Sampling Error in the Standard Evaluation of Endoscopic Colonic Biopsies
Calhoun BC, Gomes F, Robert ME, Jain D. Sampling Error in the Standard Evaluation of Endoscopic Colonic Biopsies. The American Journal Of Surgical Pathology 2003, 27: 254-257. PMID: 12548174, DOI: 10.1097/00000478-200302000-00016.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyColonColonic PolypsEndoscopyHumansIntestinal MucosaSelection BiasStaining and LabelingConceptsEndoscopic colonic biopsiesEosin-stained slidesNew diagnosisColonic biopsiesMucosal biopsiesClinical impressionGastrointestinal mucosal biopsiesSpecific histopathologic diagnosisCases of discordanceAdditional hematoxylinDiagnostic informationDefinitive diagnosisHistologic abnormalitiesConsecutive casesTubular adenomaHistopathologic diagnosisHyperplastic polypsRoutine examinationBiopsyBiopsy materialHistologic impressionNew diagnostic informationDiagnosisFirst slideStandard evaluation