2020
Liver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection.
Celli R, Saffo S, Kamili S, Wiese N, Hayden T, Taddei T, Jain D. Liver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection. Archives Of Pathology & Laboratory Medicine 2020, 145: 419-427. PMID: 32810870, PMCID: PMC10960369, DOI: 10.5858/arpa.2020-0008-oa.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHCC developmentChronic hepatitis C virus (HCV) infectionChronic viral hepatitis C infectionHepatitis C virus infectionViral hepatitis C infectionTissue polymerase chain reactionAntiviral agent therapyLiver histologic findingsLiver pathologic changesNon-SVR groupOccult HCV infectionPersistent liver inflammationSuccessful DAA therapyC virus infectionHepatitis C infectionSubset of patientsDegree of inflammationNumber of patientsPresence of virusDAA therapySVR patientsVirologic responseC infectionHCV infectionFibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation
Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.Peer-Reviewed Original ResearchConceptsAdvanced Barcelona Clinic Liver Cancer stageBarcelona Clinic Liver Cancer stageScirrhous HCCMultiple rounded nodulesNon-peripheral washoutLiver Cancer stageRadiological featuresClinical featuresRadiological correlationCarcinoma variantsCancer stageHCC casesHepatocellular carcinomaLiver cancerFibrotic liverConventional HCCHCCLower ratesHigh rateRounded nodulesProgressionDistinct patternsCarcinomaSpecific variantsLesions
2019
Macrotrabecular Hepatocellular Carcinoma
Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-FetoproteinsCarcinoma, HepatocellularDisease ProgressionFemaleHepatectomyHepatitis BHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk FactorsTime FactorsTumor BurdenConceptsHepatocellular carcinomaHCC subtypesHigh alpha-fetoprotein levelsWorse recurrence-free survivalDistinct HCC subtypeHepatitis C infectionRecurrence-free survivalAlpha-fetoprotein levelsAnaplastic tumor cellsHigh histologic gradePoor overall survivalConventional hepatocellular carcinomaHigh recurrence rateHigher AJCC stageDetailed pathologic evaluationMacrotrabecular patternC infectionPrimary resectionHepatitis BOverall survivalPathologic evaluationAJCC stageClinicopathologic featuresHistologic subtypeRecurrence rate
2005
Histological-hemodynamic correlation in cirrhosis—a histological classification of the severity of cirrhosis
Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G. Histological-hemodynamic correlation in cirrhosis—a histological classification of the severity of cirrhosis. Journal Of Hepatology 2005, 44: 111-117. PMID: 16274836, DOI: 10.1016/j.jhep.2005.07.036.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientPresence of CSPHSeverity of cirrhosisSeptal thicknessSmall nodularityPortal hypertensionPortal tractsBiopsy-proven cirrhosisSpecific histological parametersVenous pressure gradientDevelopment of complicationsNodule sizeHistological cirrhosisSinusoidal fibrosisAlcoholic etiologyHVPG measurementIndependent predictorsDefinitive diagnosisHistological classificationBACKGROUND/CirrhosisHistological parametersCentral veinNodularityCSPH
2004
Rapid Progression of Autoimmune Hepatitis in the Background of Primary Sclerosing Cholangitis
Hong-Curtis J, Yeh M, Jain D, Lee JH. Rapid Progression of Autoimmune Hepatitis in the Background of Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2004, 38: 906-909. PMID: 15492611, DOI: 10.1097/00004836-200411000-00015.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisAutoimmune hepatitisOverlap syndromeSclerosing cholangitisLiver diseaseHemolytic anemiaAIH/PSC overlap syndromePrompt recoveryDiagnosis of AIHPatient's prompt recoveryAutoimmune liver diseaseAutoimmune hemolytic anemiaProgressive liver failurePrimary biliary cirrhosisAcidophil bodiesAutoimmune cholangitisInterface hepatitisImmunosuppressive therapyBiliary cirrhosisLiver biopsyLiver failureLymphoplasmacytic infiltrateUlcerative colitisClinical symptomsLiver function