2011
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells
Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Jain D, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ. Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells. European Journal Of Immunology 2011, 41: 2782-2792. PMID: 21660940, PMCID: PMC3517133, DOI: 10.1002/eji.201141678.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalGenes, T-Cell ReceptorGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunologic MemoryIsoantigensLymphocyte ActivationMicePostoperative ComplicationsSkin TransplantationT-Cell Antigen Receptor SpecificityT-Lymphocyte SubsetsConceptsEffector memory T cellsMemory T cellsSkin graft rejectionLymphopenia-induced proliferationT cellsMild GVHDAlloreactive clonesGraft rejectionAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationT cell receptor repertoireGVHD effector cellsDonor T cellsStem cell transplantationDiverse T cell receptor repertoireNaive T cellsRapid skin graft rejectionAlloreactive repertoireGVHD inductionLimited GVHDHost diseaseLeukemia effectEffector cellsCell transplantationSyngeneic recipients
2010
Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction
Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD. Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction. Transplantation And Cellular Therapy 2010, 16: 1222-1230. PMID: 20338255, PMCID: PMC3135976, DOI: 10.1016/j.bbmt.2010.03.015.Peer-Reviewed Original ResearchConceptsRecipient B cellsAntigen presenting cellsB cellsAllogeneic hematopoietic stem cell transplantationB cell-deficient recipientsImportant antigen presenting cellsRecipient antigen presenting cellsAllogeneic bone marrow transplantationHematopoietic stem cell transplantationCD8-mediated GVHDHost disease inductionB-cell depletionAntibody-mediated depletionHost B cellsCD20 monoclonal antibodyStem cell transplantationT cell responsesBone marrow transplantationGraft-VersusAPC subsetsHost diseaseMarrow transplantationCell depletionCell transplantationPresenting cells
2008
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 2008, 111: 5242-5251. PMID: 18285547, PMCID: PMC2384145, DOI: 10.1182/blood-2007-09-107953.Peer-Reviewed Original ResearchConceptsSecondary lymphoid tissuesT cellsMemory phenotype CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationHost disease inductionCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsT cell traffickingGVHD initiationMild GVHDHost diseaseTransplant recipientsTumor effectCell transplantationLymphoid tissueGVHDDisease inductionImmune responseCD62LCCR7Major causeGraftCD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL
Matte-Martone C, Liu J, Jain D, McNiff J, Shlomchik WD. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 2008, 111: 3884-3892. PMID: 18223170, PMCID: PMC2275040, DOI: 10.1182/blood-2007-11-125294.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalGraft vs Host DiseaseGraft vs Leukemia EffectHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMice, KnockoutMinor Histocompatibility AntigensReceptors, Antigen, T-CellStem Cell TransplantationTransplantation ChimeraTransplantation, HomologousConceptsCD4 cellsT cellsT cell antigen receptorAllogeneic stem cell transplantationMajor histocompatibility complex class IDirect cytolytic actionDistinct effector mechanismsDonor CD4 cellsDonor T cellsStem cell transplantationHistocompatibility complex class IMinor H antigensClass II moleculesComplex class IHost diseaseBCR-ABL cDNAGVHDEffector mechanismsMouse modelCML cellsBone marrowCognate interactionNoncytolytic pathwaysCD8Cytolytic action
2007
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
Zheng H, Matte-Martone C, Li H, Anderson BE, Venketesan S, Tan H, Jain D, McNiff J, Shlomchik WD. Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood 2007, 111: 2476-2484. PMID: 18045967, PMCID: PMC2234071, DOI: 10.1182/blood-2007-08-109678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesGraft vs Host DiseaseGraft vs Leukemia EffectHematopoietic Stem Cell TransplantationHistocompatibility TestingImmunologic MemoryLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphocyte TransfusionMajor Histocompatibility ComplexMiceTransplantation, HomologousConceptsDonor T cellsT cellsHost diseaseAllogeneic hematopoietic stem cell transplantationFunctional T-cell memoryPerforin-deficient T cellsT-cell-depleted allograftsEffector memory T cellsHematopoietic stem cell transplantationDirect cytolytic functionNonmalignant host tissuesEffector memory CD4Memory T cellsStem cell transplantationT cell memoryBlast crisis chronic myelogenous leukemiaRelevant mouse modelChronic myelogenous leukemiaApplicable cell therapyRecipient alloantigensImmune reconstitutionLeukemia effectMemory CD4Chronic phaseCell transplantation
2004
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
Anderson BE, McNiff JM, Jain D, Blazar BR, Shlomchik WD, Shlomchik MJ. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 2004, 105: 2227-2234. PMID: 15522961, DOI: 10.1182/blood-2004-08-3032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseDisease Models, AnimalGraft vs Host DiseaseIntestinal DiseasesMembrane GlycoproteinsMiceMice, Inbred BALB COrgan SpecificitySkin DiseasesTransplantation, HomologousConceptsHost antigen-presenting cellsAntigen-presenting cellsDonor antigen-presenting cellsChronic GVHDAcute GVHDHost diseaseAPC requirementsHost-derived antigen-presenting cellsAllogeneic stem cell transplantationMurine chronic graftCD8 T cellsStem cell transplantationChronic graftGVHD therapyCell transplantationChronic formCostimulatory moleculesGVHDT cellsTarget organsAPC functionCD80/86Pathogenesis mechanismsCD4GraftTarget Antigens Determine Graft-versus-Host Disease Phenotype
Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD. Target Antigens Determine Graft-versus-Host Disease Phenotype. The Journal Of Immunology 2004, 173: 5467-5475. PMID: 15494494, DOI: 10.4049/jimmunol.173.9.5467.Peer-Reviewed Original ResearchConceptsHost diseaseSkin diseasesBALB/c recipientsAllogeneic stem cell transplantationBALB/c miceSubset of patientsStem cell transplantationT cell repertoireKey pathologic featuresBALB/cX BALB/Host disease phenotypesCutaneous cGVHDMurine donorsSystemic GVHDC recipientsFrequent complicationCutaneous fibrosisPathologic featuresSystemic diseaseB miceCell transplantationC miceK miceImmunodominant Ag