2021
Clinicopathological significance of neutrophil-rich colorectal carcinoma
Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. Journal Of Clinical Pathology 2021, 76: 34-39. PMID: 34312298, PMCID: PMC10910606, DOI: 10.1136/jclinpath-2021-207702.Peer-Reviewed Original ResearchMeSH KeywordsColorectal NeoplasmsDNA Mismatch RepairHumansNeoplastic Syndromes, HereditaryNeutrophilsPrognosisConceptsRecurrence-free survivalColorectal carcinomaHistological gradeTumor locationRight-sided tumor locationTumor cellsDNA mismatch repair (MMR) statusIndependent risk factorKaplan-Meier analysisHigh histological gradeAdvanced TNM stageMismatch repair statusPrognostic significanceCRC casesClinicopathological significanceTNM stageMetastasis stagePatient prognosisRisk factorsClinicopathological parametersMultivariate analysisRepair statusPatientsCarcinomaHigh rate
2020
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature 2020, 580: 524-529. PMID: 32322056, PMCID: PMC7490650, DOI: 10.1038/s41586-020-2166-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, LyArachidonic AcidCarcinogenesisCell Cycle ProteinsCell ProliferationColorectal NeoplasmsCyclooxygenase 2DinoprostoneFemaleFibroblastsHumansIntestinal MucosaIntestinesMaleMembrane ProteinsMesodermMiceNeoplastic Stem CellsOrganoidsParacrine CommunicationReceptors, Prostaglandin E, EP4 SubtypeSingle-Cell AnalysisStem Cell NicheYAP-Signaling ProteinsConceptsSingle-cell RNA-sequencing analysisTumor-initiating stem cellsRNA sequence analysisMesenchymal nicheStem cellsTumor initiationSca-1Hippo pathway effector YAPStem cell functionCell expansionPathway effector YAPMutant stem cellsEpithelial-specific ablationIntestinal stem cellsEarly tumor initiationProstaglandin E2Regenerative reprogrammingNormal epithelial stem cellsParacrine controlTumorigenic programsNiche modelsNuclear localizationTranscriptional activityYAP dephosphorylationEpithelial stem cells
2019
Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis
Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2019, 44: 241-246. PMID: 31498179, DOI: 10.1097/pas.0000000000001369.Peer-Reviewed Original ResearchConceptsHigh-grade tumor buddingAdverse histologic featuresMalignant polypsNodal metastasisTumor buddingHistologic featuresLymphovascular invasionNode metastasisLymph node metastatic potentialMargin statusSubsequent resectionColectomy specimenColectomy proceduresDifferentiated clustersTumor differentiationOdds ratioRisk featuresMetastasisMetastatic potentialPiecemeal polypectomyPolypsRiskInvasionColectomyResection
2011
Narrow Band Imaging Features and Pathological Correlations of Sessile Serrated Polyps
Gancayco J, Siddiqui UD, Jain D, Aslanian HR. Narrow Band Imaging Features and Pathological Correlations of Sessile Serrated Polyps. The American Journal Of Gastroenterology 2011, 106: 1559. PMID: 21811282, DOI: 10.1038/ajg.2011.122.Peer-Reviewed Original Research