2022
An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center.
Wang JD, Sebastian C, Walther Z, Suresh T, Lacy J, Zhang X, Jain D. An Appraisal of Immunohistochemical Stain Use in Hepatic Metastasis Highlights the Effectiveness of the Individualized, Case-Based Approach: Analysis of Data From a Tertiary Care Medical Center. Archives Of Pathology & Laboratory Medicine 2022, 147: 185-192. PMID: 35512224, DOI: 10.5858/arpa.2021-0457-oa.Peer-Reviewed Original ResearchConceptsLiver biopsyUnknown primaryIHC markersPrimary siteTrue carcinomaTertiary care medical centerAvailable clinicopathologic dataSquamous cell carcinomaClinicopathologic dataHepatic metastasesNonepithelial tumorsCell carcinomaInstitutional databaseClinical managementStain usePractice patternsNeuroendocrine neoplasmsImmunohistochemical markersMedical CenterMorphologic patternsIndividualized approachCarcinomaBiopsyMetastasisTumors
2020
Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver
Cheng L, Jain D, Kakar S, Torbenson MS, Wu TT, Yeh MM. Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver. Human Pathology 2020, 108: 93-99. PMID: 33245984, DOI: 10.1016/j.humpath.2020.11.012.Peer-Reviewed Original ResearchConceptsGenetic metabolic disordersMetabolic disordersHepatocellular neoplasmsBackground liverType 1Ornithine carbamyl transferase deficiencyRare genetic metabolic disorderRare case reportBackground liver parenchymaGlycogen storage disease type 1Hereditary tyrosinemia type 1Disease type 1Tyrosinemia type 1Younger patientsRetrospective studyCase reportCommon findingLiver parenchymaSteatosisTransferase deficiencyPathological characterizationNeoplasmsTumorsDisordersPatients
2019
Proinsulin Expressing Neuroendocrine Tumors of the Pancreas
Celli R, Tang LH, Cai G, Freedman-Weiss M, Colunga M, Salem RR, Majumdar S, Jain D. Proinsulin Expressing Neuroendocrine Tumors of the Pancreas. Pancreas 2019, 48: 55-59. PMID: 30451800, DOI: 10.1097/mpa.0000000000001196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsAvailable clinicopathologic dataIHC-negative tumorsSurgical oncology centersNormal insulin levelsIHC-positive tumorsSerum proinsulinClinicopathologic featuresPNET patientsClinicopathologic dataHypoglycemic patientsInsulin levelsProspective studyOncology centersSerum glucoseSuch tumorsClinical significanceInsulin immunohistochemistryRare casePatientsImmunohistochemistryProinsulinomaTumorsInsulinoma
2017
A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors
Murtha TD, Lupsa BC, Majumdar S, Jain D, Salem RR. A Systematic Review of Proinsulin-Secreting Pancreatic Neuroendocrine Tumors. Journal Of Gastrointestinal Surgery 2017, 21: 1335-1341. PMID: 28510792, DOI: 10.1007/s11605-017-3428-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsSystematic reviewRare pancreatic neuroendocrine tumorYale-New Haven HospitalMajority of patientsMedian tumor diameterLower insulin levelsBiomedical databases PubMedNew Haven HospitalSymptomatic hypoglycemiaMost patientsFemale predominanceTumor diameterClinicopathologic featuresInsulin levelsUncommon diseaseMean ageOvid MEDLINEHormonal levelsDatabases PubMedPatientsProinsulinomaHormone productionTumors
2011
Pseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases
Kenney B, Singh G, Salem RR, Paterno F, Robert ME, Jain D. Pseudointraductal papillary mucinous neoplasia caused by microscopic periductal endocrine tumors of the pancreas: a report of 3 cases. Human Pathology 2011, 42: 1034-1041. PMID: 21292301, DOI: 10.1016/j.humpath.2010.09.018.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmMucinous neoplasmsEndocrine tumorsPancreatic ductEndocrine neoplasmsDistinctive pancreatic tumorsExtensive mucin productionMain pancreatic ductPancreatic endocrine tumorsConstellation of findingsPancreatic endocrine neoplasmsDuct stricturesMucinous neoplasiaCystic lesionsPancreatic tumorsMucin productionNeoplasmsPapillary epitheliumTumorsDuctSuch casesConvincing featuresResectionStricture
2010
Benign tumors and tumor-like lesions of the gallbladder and extrahepatic biliary tract
Van Patten K, Jain D. Benign tumors and tumor-like lesions of the gallbladder and extrahepatic biliary tract. Diagnostic Histopathology 2010, 16: 371-379. DOI: 10.1016/j.mpdhp.2010.06.001.Peer-Reviewed Original ResearchTumor-like lesionsBenign tumorsChronic cholecystitisTypes of metaplasiaExtrahepatic bile ductExtrahepatic biliary tractSoft tissue counterpartsSurgical pathology laboratoryBiliary typeBiliary tractBile ductNeurogenic lesionsMesenchymal tumorsEpithelial tumorsBenign lesionsLesionsGallbladderTumorsTissue counterpartsPathology laboratoryWrong diagnosisCholecystitisMalignancyCommon specimensVast majority
2007
Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report
Neto AG, Dainiak C, Qin L, Salem RR, Jain D. Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report. Digestive Diseases And Sciences 2007, 52: 2643-2645. PMID: 17394067, DOI: 10.1007/s10620-007-9777-5.Peer-Reviewed Original ResearchConceptsIntraductal papillary cholangiocarcinomaVon Meyenberg complexesColicky right upper quadrant painRight upper quadrant painBile duct neoplasmsFine fibrovascular coresGastric foveolar typeUpper quadrant painBiliary colicPapillary cholangiocarcinomaQuadrant painLeft hepatectomyBile ductLeft lobeCase reportFibrovascular coresPapillary frondsFoveolar typePeribiliary glandsRare caseLiver parenchymaRare formImaging studiesEnglish literatureTumors
2000
Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
Jain D, Parkash V, Li M, Gill J, Crouch J, Howe G, Tallini G. Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases. Archives Of Pathology & Laboratory Medicine 2000, 124: 1369-72. PMID: 10975941, DOI: 10.5858/2000-124-1369-ebvrda.Peer-Reviewed Original ResearchConceptsGlandular differentiationNasopharyngeal typeUndifferentiated carcinomaEpstein-Barr virus latent membrane proteinEpstein-Barr virus genomeSquamous cell carcinomaLatent membrane proteinVirus RNA detectionCell carcinomaMost tumorsNasopharyngeal carcinomaCarcinomaTumorsRNA detectionUndifferentiated areasNasopharynxSitu hybridizationVirus genomeLight microscopyDifferentiationImmunohistochemistryPositivity