Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis
Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Modern Pathology 2005, 18: 1417-1423. PMID: 15920538, DOI: 10.1038/modpathol.3800449.Peer-Reviewed Original ResearchConceptsConventional hepatocellular carcinomaFibrolamellar carcinomaHepatocellular carcinomaClinicopathologic featuresOverall survivalTumor sizeMean Ki-67 indexAbsence of cirrhosisDistinct clinicopathologic featuresKi-67 indexMetastatic diseaseLymph nodesOverall mortalityDistant metastasisNonmetastatic casesPathologic featuresAggressive neoplasmNoncirrhotic liverCirrhotic liverCirrhosisKi-67Better outcomesCarcinomaProliferative activityYoung individuals