Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology 2013, 26: 782-791. PMID: 23348905, DOI: 10.1038/modpathol.2012.243.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, ScirrhousAdultAgedArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularChi-Square DistributionCholangiocarcinomaDiagnosis, DifferentialDiagnostic ErrorsFemaleGlypicansHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsConceptsScirrhous hepatocellular carcinomaClassical hepatocellular carcinomaHepatocellular carcinomaHepatocellular carcinoma casesGlypican-3Carcinoma casesMarked stromal fibrosisEpithelial cell adhesion moleculeMetastatic adenocarcinomaIntrahepatic cholangiocarcinomaStromal fibrosisCytokeratin 7Needle biopsyFrequent positivityCell adhesion moleculeHepPar-1Immunohistochemical pitfallsMorphological subtypesCarcinomaAdenocarcinomaHepatocellular differentiationCytokeratin 19Erroneous diagnosisReliable markerAdhesion molecules