2022
TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk
Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.Peer-Reviewed Original ResearchConceptsGut-liver crosstalkBile synthesisDiet-induced fatty liver diseaseSmall intestineHepatic bile saltIntestinal lipid uptakePlasma bile saltsFatty liver diseaseTreatment of NASHColorectal cancer cellsBile saltsConditional knockout modelHuman NASHFatty liverLiver diseaseFXR activationClinical trialsEnterohepatic circulationTranscription factor TCF4Fl/Hepatic levelsBile acidsEndocrine regulatorLipid uptakeIntestinal epithelium
2012
Reticulin Loss in Benign Fatty Liver
Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson M. Reticulin Loss in Benign Fatty Liver. The American Journal Of Surgical Pathology 2012, 36: 710-715. PMID: 22498821, DOI: 10.1097/pas.0b013e3182495c73.Peer-Reviewed Original ResearchConceptsLoss of reticulinFatty changeHepatic adenomaHepatocellular carcinomaReticulin stainingDiagnostic pitfallsImportant diagnostic pitfallMarked steatosisModerate steatosisNonalcoholic steatohepatitisMild steatosisFibrosis stageReticulin stainNumber of fociLiver tissueBenign fatty liverCases of steatohepatitisDegree of steatosisDegree of inflammationNon-neoplastic liver tissueAmount of steatosisMarked fatty changeCases of steatosisFine needle aspiratesFatty liver