2021
α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2002
Diagnosis of Hepatocellular Carcinoma
Jain D. Diagnosis of Hepatocellular Carcinoma. Journal Of Clinical Gastroenterology 2002, 35: s101-s108. PMID: 12394213, DOI: 10.1097/00004836-200211002-00006.Peer-Reviewed Original ResearchConceptsFine needle aspiration cytologyNeedle core biopsyHepatic massHepatic nodulesLarge hepatic massMetastatic hepatic massesHigh-risk patientsNeedle aspiration cytologyDiagnosis of HCCMost clinical settingsPositive predictive valueDifferentiated HCCRisk patientsSmall hepatic nodulesPathologic evaluationPathologic diagnosisCore biopsyDiagnostic difficultiesHistopathologic diagnosisImmunohistochemical stainsHepatocellular carcinomaInstitutional experienceAspiration cytologyHepatic lesionsPredictive value