2021
Evolution of the liver biopsy and its future
Jain D, Torres R, Celli R, Koelmel J, Charkoftaki G, Vasiliou V. Evolution of the liver biopsy and its future. Translational Gastroenterology And Hepatology 2021, 6: 20-20. PMID: 33824924, PMCID: PMC7829074, DOI: 10.21037/tgh.2020.04.01.Peer-Reviewed Original ResearchLiver biopsyLiver tissueClinical practicePost-transplant complicationsRoutine clinical practiceTissue content analysisCommon indicationLiver diseaseNon-invasive methodMultiphoton microscopyHistologic evaluationMedical disordersEffective treatmentNew therapiesBiopsyClinical diagnosisClinical researchTissue samplesVisualization of tissuesTissue sectionsPrognostic capabilityClinical workflowImproved clinical diagnosisTissueDiagnosis
2020
Motility Disorders of the Gastrointestinal Tract
Morotti R, Jain D. Motility Disorders of the Gastrointestinal Tract. Practical Anatomic Pathology 2020, 313-337. DOI: 10.1007/978-3-030-51268-2_13.Peer-Reviewed Original ResearchMotility disordersGastrointestinal tractRole of immunohistochemistryVisceral myopathyVisceral neuropathyClinical correlatesHirschsprung's diseaseHistologic characteristicsCommon disorderAdverse effectsDisordersHistochemical stainsMotility functionTractNeuropathyMedicationsImmunohistochemistryWorkupMyopathyDiseaseDiagnosis
2019
Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine
Nalbantoglu I, Jain D. Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine. Seminars In Diagnostic Pathology 2019, 36: 389-394. PMID: 31395291, DOI: 10.1053/j.semdp.2019.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCryptogenic cirrhosisCC casesLiver diseaseUnknown etiologyMain histologic findingsPossible genetic counselingChronic liver diseaseWhole-exome sequencingCirrhosis casesPediatric patientsTransplant eligibilityHistologic findingsHistologic patternPotential etiologiesHistologic examinationHistologic characterizationGenetic testingEtiologyPatientsExome sequencingDiagnostic abilityGenetic counselingGenetic alterationsDiagnosisNew disorderKnowledge gaps in the appendix: a multi-institutional study from seven academic centers
Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh MM, Torbenson MS. Knowledge gaps in the appendix: a multi-institutional study from seven academic centers. Modern Pathology 2019, 32: 988-996. PMID: 30765881, DOI: 10.1038/s41379-019-0216-x.Peer-Reviewed Original ResearchConceptsLow-grade appendiceal mucinous neoplasmGrade appendiceal mucinous neoplasmAppendiceal mucinous neoplasmGoblet cell carcinoidMucinous neoplasmsCell carcinoidExtra-appendiceal mucinHigh-risk featuresUnique diagnostic challengeHigh-grade atypiaMulti-institutional studyAppendix pathologyDiverticular diseaseMucinous adenocarcinomaDiagnostic challengeSerrated polypsAcademic centersNeoplasmsCommon knowledge gapsCarcinoidsConsultsAdenocarcinomaAdditional studiesDiagnosisPathologists
2015
Presentation of Progressive Familial Intrahepatic Cholestasis Type 3 Mimicking Wilson Disease: Molecular Genetic Diagnosis and Response to Treatment
Boga S, Jain D, Schilsky ML. Presentation of Progressive Familial Intrahepatic Cholestasis Type 3 Mimicking Wilson Disease: Molecular Genetic Diagnosis and Response to Treatment. Pediatric Gastroenterology Hepatology & Nutrition 2015, 18: 202-208. PMID: 26473142, PMCID: PMC4600706, DOI: 10.5223/pghn.2015.18.3.202.Peer-Reviewed Original ResearchProgressive familial intrahepatic cholestasis type 3Wilson's diseaseElevated hepatic copperUrine copper excretionCurrent diagnostic criteriaAutosomal recessive disorderHepatic copper contentOlder patientsHepatocellular originUrsodeoxycholic acidDiagnostic criteriaMolecular genetic diagnosisCopper excretionABCB4 geneCholestasisDiagnosisBiochemical testingHepatic copperRecessive disorderType 3Novel mutationsGenetic diagnosisDiseaseMolecular diagnosticsTreatmentComparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma
Nguyen T, Phillips D, Jain D, Torbenson M, Wu TT, Yeh MM, Kakar S. Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. Archives Of Pathology & Laboratory Medicine 2015, 139: 1028-34. PMID: 26230595, DOI: 10.5858/arpa.2014-0479-oa.Peer-Reviewed Original ResearchConceptsHep Par 1Polyclonal carcinoembryonic antigenArginase-1Hepatocellular carcinomaGlypican-3Carcinoembryonic antigenPAR-1Immunohistochemical markersSensitive markerHepatocellular differentiationLiver biopsyCarcinomaBest overall sensitivityHepatocellular markersLimited tissueAntigen 1Overall sensitivityDiagnosisCombined useReliable diagnosisPositive resultsMarkersLimited role
2014
Pathology and Staging of Rectal Cancer
Zhang X, Jain D. Pathology and Staging of Rectal Cancer. 2014, 35-56. DOI: 10.1007/978-1-4471-6609-2_4.Peer-Reviewed Original Research
2013
Pediatric Cholestatic Disorders Approach to Pathologic Diagnosis
Morotti RA, Jain D. Pediatric Cholestatic Disorders Approach to Pathologic Diagnosis. Surgical Pathology Clinics 2013, 6: 205-225. PMID: 26838972, DOI: 10.1016/j.path.2013.03.001.Peer-Reviewed Original ResearchLiver diseaseDiagnostic challengePediatric cholestatic disordersClinical featuresPediatric groupHistopathologic featuresCholestatic disordersHistopathologic findingsPathologic diagnosisDifferential diagnosisDiagnostic modalitiesBile synthesisMolecular abnormalitiesDiagnosisDiseaseDisordersSignificant overlapPathophysiologyMolecular geneticsAbnormalities
2008
Diagnostic approach to needle biopsies of hepatic mass lesions
Mitchell K, Jain D. Diagnostic approach to needle biopsies of hepatic mass lesions. Diagnostic Histopathology 2008, 14: 598-608. DOI: 10.1016/j.mpdhp.2008.09.004.Peer-Reviewed Original Research
2005
Liver Biopsy
Sheela H, Seela S, Caldwell C, Boyer JL, Jain D. Liver Biopsy. Journal Of Clinical Gastroenterology 2005, 39: 603-610. PMID: 16000929, DOI: 10.1097/01.mcg.0000170742.59134.60.Peer-Reviewed Original ResearchConceptsLiver biopsyCertain clinical settingsAutoimmune hepatitisEssential diagnostic toolLiver diseasePercutaneous approachCommon disorderIntraoperative approachDisease prognosisTherapeutic strategiesBiopsySerologic diagnosisClinical settingGenetic disordersDiagnostic toolDiagnosisDisordersLaboratory testsIndicationsHepatitisContraindicationsLaparoscopicComplicationsPrognosisDisease
2003
Sampling Error in the Standard Evaluation of Endoscopic Colonic Biopsies
Calhoun BC, Gomes F, Robert ME, Jain D. Sampling Error in the Standard Evaluation of Endoscopic Colonic Biopsies. The American Journal Of Surgical Pathology 2003, 27: 254-257. PMID: 12548174, DOI: 10.1097/00000478-200302000-00016.Peer-Reviewed Original ResearchConceptsEndoscopic colonic biopsiesEosin-stained slidesNew diagnosisColonic biopsiesMucosal biopsiesClinical impressionGastrointestinal mucosal biopsiesSpecific histopathologic diagnosisCases of discordanceAdditional hematoxylinDiagnostic informationDefinitive diagnosisHistologic abnormalitiesConsecutive casesTubular adenomaHistopathologic diagnosisHyperplastic polypsRoutine examinationBiopsyBiopsy materialHistologic impressionNew diagnostic informationDiagnosisFirst slideStandard evaluation