2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrumConsensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group
Lohse AW, Sebode M, Bhathal PS, Clouston AD, Dienes HP, Jain D, Gouw ASH, Guindi M, Kakar S, Kleiner DE, Krech T, Lackner C, Longerich T, Saxena R, Terracciano L, Washington K, Weidemann S, Hübscher SG, Tiniakos D. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group. Liver International 2022, 42: 1058-1069. PMID: 35230735, DOI: 10.1111/liv.15217.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisChronic autoimmune hepatitisLobular hepatitisLymphoplasmacytic hepatitisInflammatory changesLiver diseaseHistological featuresHistological criteriaConsensus criteriaInternational consensus criteriaExpert liver pathologistsDelphi panel approachChronic presentationAcute presentationLiver biopsyHistological diagnosisHistopathological diagnosisLiver pathologistsLiver pathologyConsensus statementConsensus recommendationsHepatitisPathology groupDisease severityPeriportal region
2019
Identification of key challenges in liver pathology: data from a multicenter study of extramural consults
Torbenson MS, Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh M. Identification of key challenges in liver pathology: data from a multicenter study of extramural consults. Human Pathology 2019, 87: 75-82. PMID: 30857968, DOI: 10.1016/j.humpath.2019.03.001.Peer-Reviewed Original ResearchConceptsLiver pathologyEtiology of cirrhosisFatty liver diseasePrimary biliary cirrhosisDiagnosis of malignancyFocal nodular hyperplasiaLiver casesAutoimmune hepatitisHepatitic patternBiliary cirrhosisLiver diseaseMetastatic malignancyMulticenter studyHepatic adenomaNodular hyperplasiaBenign tumorsConsult serviceMalignant tumorsHepatocellular carcinomaAcademic centersSpecific diagnosisTumor pathologyTumor typesConsultant diagnosesPatient care
2018
Histologic features of autoimmune hepatitis: a critical appraisal
Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Histologic features of autoimmune hepatitis: a critical appraisal. Human Pathology 2018, 82: 51-60. PMID: 30041025, DOI: 10.1016/j.humpath.2018.07.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiopsyChildChild, PreschoolDatabases, FactualEmperipolesisFemaleHepatitis C, ChronicHepatitis, AutoimmuneHepatocytesHumansKupffer CellsLiverLiver CirrhosisLymphocytesMaleMiddle AgedPlasma CellsPredictive Value of TestsReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexYoung AdultConceptsProminent plasma cellsAutoimmune hepatitisHistologic featuresPlasma cellsInflammatory gradePortal tractsScoring systemInitiation of therapySeverity of hepatitisDifferent control groupsChronic hepatitisHepatitis CFibrosis stageStudy groupDisease processHepatitisControl groupHyaline globulesFurther studiesPatientsTractCritical appraisalCellsGradeTypical features
2005
Liver Biopsy
Sheela H, Seela S, Caldwell C, Boyer JL, Jain D. Liver Biopsy. Journal Of Clinical Gastroenterology 2005, 39: 603-610. PMID: 16000929, DOI: 10.1097/01.mcg.0000170742.59134.60.Peer-Reviewed Original ResearchConceptsLiver biopsyCertain clinical settingsAutoimmune hepatitisEssential diagnostic toolLiver diseasePercutaneous approachCommon disorderIntraoperative approachDisease prognosisTherapeutic strategiesBiopsySerologic diagnosisClinical settingGenetic disordersDiagnostic toolDiagnosisDisordersLaboratory testsIndicationsHepatitisContraindicationsLaparoscopicComplicationsPrognosisDisease
2004
Rapid Progression of Autoimmune Hepatitis in the Background of Primary Sclerosing Cholangitis
Hong-Curtis J, Yeh M, Jain D, Lee JH. Rapid Progression of Autoimmune Hepatitis in the Background of Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2004, 38: 906-909. PMID: 15492611, DOI: 10.1097/00004836-200411000-00015.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisAutoimmune hepatitisOverlap syndromeSclerosing cholangitisLiver diseaseHemolytic anemiaAIH/PSC overlap syndromePrompt recoveryDiagnosis of AIHPatient's prompt recoveryAutoimmune liver diseaseAutoimmune hemolytic anemiaProgressive liver failurePrimary biliary cirrhosisAcidophil bodiesAutoimmune cholangitisInterface hepatitisImmunosuppressive therapyBiliary cirrhosisLiver biopsyLiver failureLymphoplasmacytic infiltrateUlcerative colitisClinical symptomsLiver function