Genetic analysis of biological pathway data through genomic randomization
Yaspan B, Bush W, Torstenson E, Ma D, Pericak-Vance M, Ritchie M, Sutcliffe J, Haines J. Genetic analysis of biological pathway data through genomic randomization. Human Genetics 2011, 129: 563-571. PMID: 21279722, PMCID: PMC3107984, DOI: 10.1007/s00439-011-0956-2.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderGenome-Wide Association StudyHumansLinkage DisequilibriumMetabolic Networks and PathwaysPolymorphism, Single NucleotideRandom AllocationConceptsGenome-wide association studiesGWAS datasetsWide association studyRandomization Incorporating StructurePotential epistatic effectsGWAS resultsGene sizeSNP coverageKEGG databaseBiological pathway dataSingle locusEpistatic effectsGenetic analysisPathway analysisAssociation studiesSNP allelesAssociation resultsAssociation analysis methodLinkage disequilibriumSignificant enrichmentPathway dataPathway sizeVariants of interestMultiple testing correctionSmall main effect