2024
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri H, Spencer D, Zaghloul K, Ksendzovsky A. Modeling seizure networks in neuron-glia cultures using microelectrode arrays. Frontiers In Network Physiology 2024, 4: 1441345. PMID: 39290793, PMCID: PMC11405204, DOI: 10.3389/fnetp.2024.1441345.Peer-Reviewed Original ResearchNetwork changesSeizure networkSeizure modelsDays of chronic treatmentDimensionality reductionNetwork developmentDrug-resistant epilepsyNeuron-glia culturesMean firing rateNetworkTreatment failureChronic treatmentMicroelectrode arraysResection surgeryRetrospective studyFiring rateSeizuresExperience seizuresNeurological disordersStability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bandsMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesCombined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisA CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring
Gu Y, Vazquez J, Murray D, Zaveri H, Spencer D. A CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring. 2024, 00: 693-697. DOI: 10.1109/ectc51529.2024.00113.Peer-Reviewed Original ResearchOptimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data
Iktimal A, Spencer D, Alkawadri R. Optimized Multilayer Perceptron for Sensorimotor Functional Mapping Based on a Few Minutes of Intracranial Electroencephalogram Data. Annals Of Neurology 2024, 96: 187-193. PMID: 38506405, DOI: 10.1002/ana.26915.Peer-Reviewed Original ResearchMultilayer perceptronTanh activation functionArea under the curveMultilayer Perceptron performanceOptimal multilayer perceptronImbalanced dataF1 scoreFeature extensionNeural networkActivation functionElectroencephalogram-dataSensorimotor cortexIntractable epilepsy patientsPerceptronCentral sulcusCross-validationAnterior lipEpilepsy patientsGaussian distribution functionFunctional mappingNetworkMetricsSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsSeizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video
Merenzon M, Lamsam L, McGrath H, Sivaraju A, Hirsch L, Cukiert A, Zibly Z, Spencer D, Damisah E. Seizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video. Operative Neurosurgery 2024, 27: 262-263. PMID: 39007609, DOI: 10.1227/ons.0000000000001109.Peer-Reviewed Original ResearchFunctional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
Mahgoub R, Bayram A, Spencer D, Alkawadri R. Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions. Journal Of Neurology Neurosurgery & Psychiatry 2024, 95: jnnp-2023-332246. PMID: 38242679, DOI: 10.1136/jnnp-2023-332246.Peer-Reviewed Original ResearchPosterior cingulate cortexCingulate gyrusElectrical cortical stimulationCingulate cortexFunctional capacitySystematic reviewInclusion criteriaAnterior cingulate cortexCortical stimulationCingulate functionComplex motor behaviorsCingulate subregionsComplex motorLimbic systemBrain structuresCingulateSpeech responsesSimple motorLiterature reviewMotor behaviorSurgical planningFunctional parcellationAutonomic responsesCorpus callosumImaging modalities
2023
Comparison of Machine Learning Algorithms for Somatosensory Functional Mapping (S30.010)
Alwan I, Spencer D, Alkawadri R. Comparison of Machine Learning Algorithms for Somatosensory Functional Mapping (S30.010). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203115.Peer-Reviewed Original Research
2020
Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255)
Henriquez-Rojas P, Torabi T, Farooque P, Hirsch L, Duckrow R, Herlopian A, Spencer D, Gerrard J, Quraishi I. Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1255.Peer-Reviewed Original Research
2019
Glossokinetic Potentials: Insights from intracranial EEG (P4.5-014)
Bayram A, Spencer D, Alkawadri R. Glossokinetic Potentials: Insights from intracranial EEG (P4.5-014). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p4.5-014.Peer-Reviewed Original Research
2018
Effect of Anesthesia on Electrocorticography for localization of Epileptic Focus: Literature Review and Future Directions (P2.271)
Bayram A, Rao S, Spencer D, Alkawadri R. Effect of Anesthesia on Electrocorticography for localization of Epileptic Focus: Literature Review and Future Directions (P2.271). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p2.271.Peer-Reviewed Original ResearchBrief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299)
Isitan C, Benjamin C, Quraishi I, Spencer D, Alkawadri R. Brief History of Electrical Cortical Stimulation: A Journey in time from Volta to Penfield (P5.299). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p5.299.Peer-Reviewed Original Research
2017
Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107)
Farooque P, Stanford E, Rechnitzer A, Bandt K, Bonito J, Spencer D, Hirsch L. Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p4.107.Peer-Reviewed Original Research
2006
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyPhosphate-activated glutaminaseLobe epilepsyHippocampal formationHuman mesial temporal lobe epilepsyWestern blotElevation of glutamateNon-epileptogenic hippocampusElevated glutamate levelsDouble-labeling experimentsRecurrent seizuresDentate gyrusPolymorphic layerExtracellular glutamateGlutamate levelsHippocampal homogenatesGlutamate homeostasisHippocampal neuronsBasal concentrationsPAG immunoreactivityPatientsNeuronsNumber of neuronsEpilepsyDifferential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activityNonrigid 3D Brain Registration Using Intensity/Feature Information
DeLorenzo C, Papademetris X, Wu K, Vives KP, Spencer D, Duncan JS. Nonrigid 3D Brain Registration Using Intensity/Feature Information. Lecture Notes In Computer Science 2006, 9: 932-939. PMID: 17354980, PMCID: PMC2864121, DOI: 10.1007/11866565_114.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceBayes TheoremBrainEpilepsyHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueSurgery, Computer-AssistedConceptsStereo camera imagesCamera calibration errorsPreoperative brain imagesSurface tracking algorithmFeature informationCamera imagesTracking algorithmBrain imagesOptimization termSurface detectionRobust modelImagesBrain registrationIntraoperative brainCalibration errorsAlgorithmAccuracyRegistrationModelInformation
1985
Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy.
Goodman R, Williamson P, Reeves A, Spencer S, Spencer D, Mattson R, Roberts D. Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy. Neurology 1985, 35: 1351-4. PMID: 4022384, DOI: 10.1212/wnl.35.9.1351.Peer-Reviewed Original Research
1984
Intracerebral masses in patients with intractable partial epilepsy.
Spencer D, Spencer S, Mattson R, Williamson P. Intracerebral masses in patients with intractable partial epilepsy. Neurology 1984, 34: 432-6. PMID: 6422323, DOI: 10.1212/wnl.34.4.432.Peer-Reviewed Original ResearchConceptsPartial seizuresSubtotal lobectomyUncontrolled partial seizuresGood seizure controlIntractable partial epilepsySimple partial seizuresIntracranial mass lesionsForm of treatmentSeizure controlMass resectionNeurologic examinationPreoperative evaluationSurgical treatmentIntracerebral massPartial epilepsyRadiologic studiesMass lesionStructural lesionsPatientsSeizuresLesionsLobectomyNeoplasmsTreatmentResection