Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyPhosphate-activated glutaminaseLobe epilepsyHippocampal formationHuman mesial temporal lobe epilepsyWestern blotElevation of glutamateNon-epileptogenic hippocampusElevated glutamate levelsDouble-labeling experimentsRecurrent seizuresDentate gyrusPolymorphic layerExtracellular glutamateGlutamate levelsHippocampal homogenatesGlutamate homeostasisHippocampal neuronsBasal concentrationsPAG immunoreactivityPatientsNeuronsNumber of neuronsEpilepsyDifferential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activity