2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesSeizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video
Merenzon M, Lamsam L, McGrath H, Sivaraju A, Hirsch L, Cukiert A, Zibly Z, Spencer D, Damisah E. Seizing Control: Primary Visual Cortex Epilepsy Treated With Resection and Responsive Neurostimulation: 2-Dimensional Operative Video. Operative Neurosurgery 2024, 27: 262-263. PMID: 39007609, DOI: 10.1227/ons.0000000000001109.Peer-Reviewed Original Research
2006
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyPhosphate-activated glutaminaseLobe epilepsyHippocampal formationHuman mesial temporal lobe epilepsyWestern blotElevation of glutamateNon-epileptogenic hippocampusElevated glutamate levelsDouble-labeling experimentsRecurrent seizuresDentate gyrusPolymorphic layerExtracellular glutamateGlutamate levelsHippocampal homogenatesGlutamate homeostasisHippocampal neuronsBasal concentrationsPAG immunoreactivityPatientsNeuronsNumber of neuronsEpilepsyDifferential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activity
1985
Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy.
Goodman R, Williamson P, Reeves A, Spencer S, Spencer D, Mattson R, Roberts D. Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy. Neurology 1985, 35: 1351-4. PMID: 4022384, DOI: 10.1212/wnl.35.9.1351.Peer-Reviewed Original Research
1984
Intracerebral masses in patients with intractable partial epilepsy.
Spencer D, Spencer S, Mattson R, Williamson P. Intracerebral masses in patients with intractable partial epilepsy. Neurology 1984, 34: 432-6. PMID: 6422323, DOI: 10.1212/wnl.34.4.432.Peer-Reviewed Original ResearchConceptsPartial seizuresSubtotal lobectomyUncontrolled partial seizuresGood seizure controlIntractable partial epilepsySimple partial seizuresIntracranial mass lesionsForm of treatmentSeizure controlMass resectionNeurologic examinationPreoperative evaluationSurgical treatmentIntracerebral massPartial epilepsyRadiologic studiesMass lesionStructural lesionsPatientsSeizuresLesionsLobectomyNeoplasmsTreatmentResection
1983
Sexual automatisms in complex partial seizures.
Spencer S, Spencer D, Williamson P, Mattson R. Sexual automatisms in complex partial seizures. Neurology 1983, 33: 527-33. PMID: 6682492, DOI: 10.1212/wnl.33.5.527.Peer-Reviewed Original ResearchConceptsComplex partial seizuresSexual automatismsPartial seizuresRefractory complex partial seizuresTemporal lobe diseaseFrontal lobe pathologySeizure frequencyFrontal lobectomySeizure focusSeizure originCalcified lesionsPatientsPelvic thrustingFrontal lobeSeizuresDepth EEGMasturbatory activityAutomatismsLobectomyLesionsDiseasePathology