Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyPhosphate-activated glutaminaseLobe epilepsyHippocampal formationHuman mesial temporal lobe epilepsyWestern blotElevation of glutamateNon-epileptogenic hippocampusElevated glutamate levelsDouble-labeling experimentsRecurrent seizuresDentate gyrusPolymorphic layerExtracellular glutamateGlutamate levelsHippocampal homogenatesGlutamate homeostasisHippocampal neuronsBasal concentrationsPAG immunoreactivityPatientsNeuronsNumber of neuronsEpilepsy