Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury
Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultArea Under CurveBiomarkersCohort StudiesCreatinineCross-Sectional StudiesFatty Acid-Binding ProteinsFemaleHepatitis A Virus Cellular Receptor 1HumansInterleukin-18Kidney TransplantationKidney TubulesLipocalin-2MaleMiddle AgedProspective StudiesROC CurveSeverity of Illness IndexTissue DonorsConceptsSevere acute tubular injuryAcute kidney injuryAcute tubular injuryTubular injurySCr concentrationNGAL concentrationsUrinary biomarkersDeceased donorsOrgan procurementMulticenter prospective cohortUrinary L-FABPUrinary NGAL concentrationsDeceased kidney donorsKidney injury biomarkersSerum creatinine concentrationPoor diagnostic performanceAKI casesAKI causesDonor hospitalizationKidney injuryProspective cohortSerum creatinineInjury biomarkersKidney biopsyIL-18Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease
Coca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRandomized Controlled Trials as TopicReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIConceptsKidney injury molecule-1Diabetic kidney diseaseTNF receptor 1Progressive diabetic kidney diseaseRenal outcomesTNFR-2Kidney diseaseBaseline levelsAdvanced diabetic kidney diseaseIncident diabetic kidney diseaseKIM-1 levelsKidney function declineInjury molecule-1Prospective cohort studyBaseline plasma samplesBiomarkers of inflammationClinical prognostic modelDiverse pathophysiologic mechanismsType 2 diabetesCase-control studyHigher baseline levelsEGFR declineCohort studyFunction declinePathophysiologic mechanisms