2024
B-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis
Obeid W, Moledina D, Parikh C. B-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis. Clinical Chemistry 2024, 70: hvae106.600. DOI: 10.1093/clinchem/hvae106.600.Peer-Reviewed Original ResearchAcute interstitial nephritisDiagnosis of acute interstitial nephritisTNF-aMesoscale DiscoveryCXCL-9Urinary tumor necrosis factor-alphaInterstitial nephritisUrine biomarker assayTumor necrosis factor-alphaNecrosis factor-alphaSpike-recovery analysisFactor-alphaPotential diagnostic biomarkersLevels of QCBiomarker assaysDiagnostic biomarkersAssay diluentDilution linearityNephritisAverage recoverySpiking volumeHospital settingLigand 9UrineDiagnosis
2022
Clinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis
Kodali R, Moledina D. Clinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis. 2022, 245-255. DOI: 10.1007/978-3-030-93438-5_19.ChaptersAcute tubulointerstitial nephritisKidney functionTubulointerstitial nephritisEvaluation of urineNon-invasive testsPresenting featuresKidney biopsyClinical featuresMedication historyHistological diagnosisLaboratory findingsHigh indexClinical usePatientsDiagnosisCareful evaluationTemporal associationNephritisSubtle cluesBiopsyCliniciansDiseaseSuspicionUrine
2021
Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients
George S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Perez A, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB, Team A. Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients. Kidney360 2021, 2: 924-936. PMID: 35373072, PMCID: PMC8791366, DOI: 10.34067/kid.0002172021.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinSARS-CoV-2Spike proteinUrine samplesSARS-CoV-2 infectionYale-New Haven HospitalCOVID-19 patientsAntigen capture assayDetectable viral RNANew Haven HospitalPositive PCR resultsPossible long-term consequencesSpike S1 proteinNP PCRChildren's HospitalNasopharyngeal swabsSARS-CoV-2 spike S1 proteinRenal abnormalitiesLong-term effectsCystatin CLong-term consequencesHospitalUrineViral RNAAlbuminuria