2017
Effects of Adrenomedullin and Glucagon-like Peptide on Distal Flap Necrosis and Vascularity: The Role of Receptor Systems and Nitric Oxide.
Cam B, Bagdas D, Ozyigit M, Sagdilek E, Buyukcoskun N, Ozluk K. Effects of Adrenomedullin and Glucagon-like Peptide on Distal Flap Necrosis and Vascularity: The Role of Receptor Systems and Nitric Oxide. WOUNDS A Compendium Of Clinical Research And Practice 2017, 29: 163-167. PMID: 28355142.Peer-Reviewed Original ResearchMeSH KeywordsAdrenomedullinAnimalsAntioxidantsCalcitonin Gene-Related PeptideDisease Models, AnimalEpigastric ArteriesFemaleGlucagon-Like Peptide ReceptorsGlucagon-Like PeptidesGraft SurvivalImmunohistochemistryNecrosisNitric OxideRatsRats, WistarReceptors, Calcitonin Gene-Related PeptideSurgical FlapsWound HealingWounds and InjuriesConceptsGlucagon-like peptide-1Superficial inferior epigastric arteryEffects of adrenomedullinFlap healingNitric oxideFlap necrosisReceptor antagonistNecrosis areaGLP-1 receptor antagonistCalcitonin gene-related peptide receptorAdult female Wistar ratsGene-related peptide receptorBeneficial effectsADM receptor antagonistAdministration of adrenomedullinPostoperative day 7Inferior epigastric arteryGLP-1 receptorDistal flap necrosisFemale Wistar ratsGlucagon-like peptideMajor complicationsCGRP receptorsEpigastric arteryWistar rats
2016
Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats
Bagdas D, Etoz B, Gul Z, Ozyigit M, Cinkilic N, Inan S, Buyukcoskun N, Ozluk K, Gurun M. Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats. Annals Of Plastic Surgery 2016, 77: e21-e25. PMID: 25356637, DOI: 10.1097/sap.0000000000000313.Peer-Reviewed Original ResearchConceptsFlap survivalDiabetic ratsEpigastric arteryFlap tissueMg/0.5 mLEffects of CGASkin flap survivalPostoperative day 7Abdominal skin flapSkin flap modelGreater flap survivalChlorogenic acidCGA treatmentFemoral arteryLocal injectionAntioxidant activitySingle arteryCapillary densityDismutase levelsMalondialdehyde levelsSkin flapsDay 7ArteryFlap modelRats
2014
Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy
Bagdas D, Ozboluk H, Cinkilic N, Gurun M. Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy. Journal Of Medicinal Food 2014, 17: 730-732. PMID: 24611441, DOI: 10.1089/jmf.2013.2966.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painAntinociceptive effectNeuropathic painChronic treatmentPainful diabetic neuropathyPossible antinociceptive effectSignificant antinociceptive effectChlorogenic acid treatmentChlorogenic acidDiabetic neuropathyNondiabetic ratsDiabetic ratsSingle doseAntinociceptive potentialRatsBeneficial effectsPainTreatmentPresent studyNeuropathyStreptozotocinHyperglycemiaDiabetesDose
2013
Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats
Bagdas D, Etoz B, Ozturkoglu S, Cinkilic N, Ozyigit M, Gul Z, Buyukcoskun N, Ozluk K, Gurun M. Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats. Biological And Pharmaceutical Bulletin 2013, 37: 361-370. PMID: 24389556, DOI: 10.1248/bpb.b13-00635.Peer-Reviewed Original ResearchConceptsSkin flap survivalFlap survivalDiabetic ratsNondiabetic ratsCapillary densityBlood perfusionVascular endothelial growth factor (VEGF) expressionPostoperative day 7Nitric oxide levelsMale Wistar ratsDorsal skin flapDorsal skin flap modelSkin flap modelGrowth factor expressionPotent antioxidant effectsChlorogenic acidRegional blood perfusionCGA treatmentWistar ratsSOD levelsOxide levelsSkin flapsNO levelsFlap tissueDay 7