2024
Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
Bagdas D, Zepei A, Harris L, Minanov K, Jimenez J, Addy N. Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors. Psychopharmacology 2024, 241: 2241-2253. PMID: 38839631, DOI: 10.1007/s00213-024-06630-9.Peer-Reviewed Original ResearchTaste reactivity testNicotine choiceNicotine takingTwo-bottle free choice testSeeking behaviorOral nicotine intakeNicotine preferenceFree-choice testNicotine intakeIngestive responsesOral nicotineDecreased dislikeAversive responsesOral cuesYoung adult Sprague Dawley ratsOrosensory propertiesAdult Sprague Dawley ratsIncreased likingNicotineFemale ratsMale ratsSprague Dawley ratsTobacco productsLong-term effectsDawley rats
2021
Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats
Bagdas D, Rupprecht LE, Nunes EJ, Schillinger E, Immanuel JJ, Addy NA. Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats. Nicotine & Tobacco Research 2021, 24: 753-760. PMID: 34918123, PMCID: PMC8962681, DOI: 10.1093/ntr/ntab241.Peer-Reviewed Original ResearchConceptsTaste reactivity testOrosensory experienceAversive responsesAbuse liabilityAversive valueAversive reactionsHedonic responsesNicotine rewardTaking behaviorIntraoral cathetersImpact of mentholReactivity testOlfactory cuesOrofacial movementsDislikingLikingNicotine responseTaste stimuliSex-dependent mannerOral nicotineNicotine inducesNicotineCuesIngestive responsesExperience
2020
Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences
Bagdas D, Jackson A, Carper M, Chen RY, Akinola LS, Damaj MI. Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences. Neuropharmacology 2020, 179: 108274. PMID: 32827516, PMCID: PMC7572603, DOI: 10.1016/j.neuropharm.2020.108274.Peer-Reviewed Original ResearchConceptsOral nicotine consumptionEffect of mentholImpact of mentholNicotine consumptionFemale miceNicotine intakeΑ7 nicotinic acetylcholine receptorMenthol concentrationNicotine solutionHigher nicotine intakeAdolescent female miceMale C57BL/6J miceTwo-bottle choice paradigmWild-type miceNicotinic acetylcholine receptorsConcentration-dependent mannerOral nicotineC57BL/6J miceKO miceMale miceType miceMouse modelAcetylcholine receptorsHigh menthol concentrationAdult counterparts