2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior TherapyChildHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrusProtocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome
Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 336: 111692. PMID: 37673711, PMCID: PMC10722977, DOI: 10.1016/j.pscychresns.2023.111692.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdolescentHumansMagnetic Resonance ImagingNeurofeedbackRandomized Controlled Trials as TopicTic DisordersTicsTourette SyndromeConceptsTourette syndromeFunctional magnetic resonance imagingStudy protocolChronic tic disorderSupplementary motor areaLower functional connectivityMagnetic resonance imagingResearch study protocolLarge trialsClinical trialsTic disordersMotor areaBrain areasControl groupResonance imagingBrain regionsNew trialsFunctional connectivityNeurofeedback interventionFMRI neurofeedbackNF protocolTrialsNF studiesSyndromeIntervention
2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildElectroencephalographyHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityIntervention
2021
Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder
Morand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG. Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Cortex 2021, 147: 157-168. PMID: 35042055, PMCID: PMC8816877, DOI: 10.1016/j.cortex.2021.12.006.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderGo/NoGo taskFrontal midline theta oscillationsFrontal midline theta powerEvent-related potentialsNoGo taskHyperactivity disorderInhibitory controlTheta powerTheta oscillationsP300 latencyInhibitory control abilitiesDense-array EEG recordingsDistinct electrophysiological profileTourette syndromeNeural underpinningsElectrophysiological correlatesTask performanceBehavioral performanceElectrophysiological signaturesP300 componentBrain activityN200Control abilityTaskIncreased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses
Morand-Beaulieu S, Wu J, Mayes LC, Grantz H, Leckman JF, Crowley MJ, Sukhodolsky DG. Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 8: 241-250. PMID: 33991741, PMCID: PMC8589865, DOI: 10.1016/j.bpsc.2021.05.001.Peer-Reviewed Original ResearchConceptsTourette syndromeTic suppressionNetwork-based statisticsDefault mode networkCortical regionsRight superior frontal gyrusMode networkAge-mediated increaseFuture treatment studiesSuperior frontal gyrusAlpha-band connectivityChronic motorHigh-density electroencephalographyPhonic ticsLeft precuneusCortical areasBrain regionsTreatment studiesBrain circuitsFunctional connectivityBrain connectivityFrontal gyrusGraph theoretical analysisNeurodevelopmental disordersBrain correlates
2019
Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCross-Over StudiesHumansMagnetic Resonance ImagingNeurofeedbackSeverity of Illness IndexTicsTourette SyndromeConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback intervention
2018
Time course of clinical change following neurofeedback
Rance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, Wasylink S, Koller WN, Bloch M, Gruner P, Scheinost D, Pittenger C, Hampson M. Time course of clinical change following neurofeedback. NeuroImage 2018, 181: 807-813. PMID: 29729393, PMCID: PMC6454268, DOI: 10.1016/j.neuroimage.2018.05.001.Peer-Reviewed Original ResearchConceptsClinical changesSymptom changeTime courseBrain functionNeurofeedback studiesPotential clinical toolCrossover designControl interventionsReal neurofeedbackClinical toolTime pointsClinical populationsNeurofeedback effectsInterventionNeurofeedback sessionsNeurofeedbackCurrent brain stateWeeksBrain statesNew studiesCourseSessionsSymptoms
2017
Moderators and predictors of response to behavior therapy for tics in Tourette syndrome
Sukhodolsky DG, Woods DW, Piacentini J, Wilhelm S, Peterson AL, Katsovich L, Dziura J, Walkup JT, Scahill L. Moderators and predictors of response to behavior therapy for tics in Tourette syndrome. Neurology 2017, 88: 1029-1036. PMID: 28202705, PMCID: PMC5384839, DOI: 10.1212/wnl.0000000000003710.Peer-Reviewed Original ResearchConceptsPredictors of responseChronic tic disorderTic reductionTic disordersPsychiatric disordersYale Global Tic Severity Scale-Total Tic ScoreTic severityTourette syndromeClinical Global Impressions-Improvement scoreCo-occurring psychiatric disordersAnxiety disordersSubgroup of patientsTotal tic scoreMain outcome measuresPredictors of outcomeBehavior therapyComprehensive Behavioral InterventionAttention-deficit/hyperactivity disorderPremonitory urge severityReduction of ticsCo-occurring attention-deficit/hyperactivity disorderGreater tic severityTIC characteristicsTic improvementClinical characteristics
2014
Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome
McGuire JF, Sukhodolsky DG, Bearss K, Grantz H, Pachler M, Lombroso PJ, Scahill L. Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome. Child Psychiatry & Human Development 2014, 45: 686-694. PMID: 24477478, DOI: 10.1007/s10578-014-0437-7.Peer-Reviewed Original Research
2012
Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome
Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L. Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome. JAMA Psychiatry 2012, 69: 795-803. PMID: 22868933, PMCID: PMC3772729, DOI: 10.1001/archgenpsychiatry.2011.1528.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionTic Severity ScaleTourette syndromeBehavior therapySeverity ScaleBehavioral interventionsOutpatient research clinicTotal tic scoreLeast moderate severityChronic tic disorderGreater mean decreaseMonthly booster sessionsAdult patientsSupportive treatmentModerate severityTic scoreTic disordersPositive respondersResearch clinicBooster sessionsMean decreasePosttreatment evaluationPatients
2010
Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder
Sukhodolsky DG, Landeros-Weisenberger A, Scahill L, Leckman JF, Schultz RT. Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1155-1164.e1. PMID: 20970703, PMCID: PMC2965169, DOI: 10.1016/j.jaac.2010.08.008.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderConnors' Continuous Performance TestVisual-Motor Integration TestVisual-motor integrationContinuous Performance TestNeuropsychological functioningResponse inhibitionHyperactivity disorderCo-occurring attention-deficit/hyperactivity disorderStroop Color-Word Interference TestColor-Word Interference TestBeery Visual-Motor Integration TestAdequate control conditionsSample of childrenFine motor coordinationTourette syndromeNeuropsychological measuresPurdue Pegboard TestHealthy community control subjectsSubtle deficitsNeurobiological mechanismsNeuropsychological deficitsInterference testControl conditionPegboard Test
2009
Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2007
The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
Sukhodolsky DG, Leckman JF, Rothenberger A, Scahill L. The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 2007, 16: 51-59. PMID: 17665283, DOI: 10.1007/s00787-007-1007-3.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderTourette syndromeAbnormal neural oscillationsOscillatory activityHyperactivity disorderAbnormal oscillatory activityThalamo-cortical circuitsSymptoms of ADHDNeural oscillationsNeural oscillatory activityBasal gangliaFunctional abnormalitiesNormal brainThalamocortical regionsThalamocortical oscillationsCortical regionsTransient hyperpolarizationPrefrontal cortexNeural activityNeural communicationPathophysiologyMotor controlSyndromeBrainDisorders
2006
Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
Bloch MH, Sukhodolsky DG, Leckman JF, Schultz RT. Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome. Journal Of Child Psychology And Psychiatry 2006, 47: 551-559. PMID: 16712631, DOI: 10.1111/j.1469-7610.2005.01561.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasal GangliaChildFemaleFunctional LateralityHand StrengthHumansMaleMotor Skills DisordersNeuropsychological TestsObsessive-Compulsive DisorderPredictive Value of TestsPsychologyPsychomotor PerformanceSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTourette SyndromeConceptsGlobal psychosocial functioningPurdue Pegboard TestFine motor skill deficitsTourette syndromeTic severityPegboard TestPsychosocial functioningTic symptomsTS patientsNeuropsychological testsStudy of TSBasal ganglia dysfunctionVisual-Motor Integration TestBeery Visual-Motor Integration TestLogistic regression analysisOrdinal logistic regression analysisFine motor coordinationMotor skill deficitsNeuropsychological testing batteryGanglia dysfunctionVisual-motor integrationClinical evaluationClinical assessmentClinical measuresNeuropsychological testing
2005
Public health significance of tic disorders in children and adolescents.
Scahill L, Sukhodolsky DG, Williams SK, Leckman JF. Public health significance of tic disorders in children and adolescents. Advances In Neurology 2005, 96: 240-8. PMID: 16383223.Peer-Reviewed Original ResearchConceptsTic disordersPresence of ADHDAbsence of ADHDPublic health significanceCommunity sampleMild ticsPersistent ticsGreater disabilityVocal ticsDaily livingDisruptive behaviorChronic ticsHealth significanceDisordersClinical samplesCommunity surveyChildrenADHDMinimal consequencesMultiple motorsImpairment
2003
Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment
SUKHODOLSKY DG, SCAHILL L, ZHANG H, PETERSON BS, KING RA, LOMBROSO PJ, KATSOVICH L, FINDLEY D, LECKMAN JF. Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 98-105. PMID: 12500082, DOI: 10.1097/00004583-200301000-00016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComorbid attention-deficit/hyperactivity disorderDisruptive behaviorFamily functioningParent ratingsTeacher ratingsDiagnosis of ADHDVineland Adaptive Behavior ScalesDisruptive behavior problemsHierarchical regression analysisAdaptive Behavior ScalesBest-estimate DSM-IV diagnosesUnaffected control childrenTourette syndromeConduct problemsDelinquency scoresHyperactivity disorderADHD comorbidityDelinquent behaviorBehavior problemsDSM-IV diagnosisDependent measuresDiagnostic statusBehavior ScaleFunctional impairment