2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrusProtocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome
Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 336: 111692. PMID: 37673711, PMCID: PMC10722977, DOI: 10.1016/j.pscychresns.2023.111692.Peer-Reviewed Case Reports and Technical NotesConceptsTourette syndromeFunctional magnetic resonance imagingStudy protocolChronic tic disorderSupplementary motor areaLower functional connectivityMagnetic resonance imagingResearch study protocolLarge trialsClinical trialsTic disordersMotor areaBrain areasControl groupResonance imagingBrain regionsNew trialsFunctional connectivityNeurofeedback interventionFMRI neurofeedbackNF protocolTrialsNF studiesSyndromeIntervention
2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityInterventionPhenomenology of Tics and Sensory Urges
Leckman J, Bloch M, Sukhodolsky D, Artukoğlu B, Scahill L, King R. Phenomenology of Tics and Sensory Urges. 2022, 6-25. DOI: 10.1093/med/9780197543214.003.0002.Peer-Reviewed Original ResearchSocial and Adaptive Functioning in Tourette Syndrome
Sukhodolsky D, Kalvin C, Artukoğlu B, Eicher V, Leckman J. Social and Adaptive Functioning in Tourette Syndrome. 2022, 391-404. DOI: 10.1093/med/9780197543214.003.0023.Peer-Reviewed Original ResearchAdaptive functioningAttention-deficit/hyperactivity disorderTourette syndromeThorough clinical assessmentCo-occurring disordersHyperactivity disorderQuality of lifePsychosocial interventionsClinical assessmentBehavioral disordersSymptom severityFunctioningStandardized ratingsDisordersActive investigationImpairmentSyndromeSeverityControl of actions and tics: A psychophysiological perspective
Morand-Beaulieu S, Jordan R, Baldwin E, Zhong J, Sukhodolsky D. Control of actions and tics: A psychophysiological perspective. International Review Of Movement Disorders 2022, 3: 343-363. DOI: 10.1016/bs.irmvd.2022.01.003.Peer-Reviewed Original ResearchTourette syndromeFunctional magnetic resonance imagingTic suppressionInhibitory controlMagnetic resonance imagingChronic ticsResonance imagingBrain correlatesBrain activityPsychophysiological studiesInhibitory control taskPsychophysiological correlatesControl of actionCorrelatesPsychophysiological techniquesSyndromeControlSuppressionStudy
2021
Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder
Morand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG. Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Cortex 2021, 147: 157-168. PMID: 35042055, PMCID: PMC8816877, DOI: 10.1016/j.cortex.2021.12.006.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderGo/NoGo taskFrontal midline theta oscillationsFrontal midline theta powerEvent-related potentialsNoGo taskHyperactivity disorderInhibitory controlTheta powerTheta oscillationsP300 latencyInhibitory control abilitiesDense-array EEG recordingsDistinct electrophysiological profileTourette syndromeNeural underpinningsElectrophysiological correlatesTask performanceBehavioral performanceElectrophysiological signaturesP300 componentBrain activityN200Control abilityTaskIncreased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses
Morand-Beaulieu S, Wu J, Mayes LC, Grantz H, Leckman JF, Crowley MJ, Sukhodolsky DG. Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 8: 241-250. PMID: 33991741, PMCID: PMC8589865, DOI: 10.1016/j.bpsc.2021.05.001.Peer-Reviewed Original ResearchConceptsTourette syndromeTic suppressionNetwork-based statisticsDefault mode networkCortical regionsRight superior frontal gyrusMode networkAge-mediated increaseFuture treatment studiesSuperior frontal gyrusAlpha-band connectivityChronic motorHigh-density electroencephalographyPhonic ticsLeft precuneusCortical areasBrain regionsTreatment studiesBrain circuitsFunctional connectivityBrain connectivityFrontal gyrusGraph theoretical analysisNeurodevelopmental disordersBrain correlates
2019
Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback intervention
2018
Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome
Tudor M, Bertschinger E, Piasecka J, Sukhodolsky D. Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome. Clinical Case Studies 2018, 17: 220-232. DOI: 10.1177/1534650118782438.ChaptersTourette syndromeOppositional defiant disorderAnger outburstsPrimary clinical concernContext of TSBehavioral therapy treatmentCognitive behavioral therapy treatmentCognitive behavioral therapySelect supplementsUseful treatmentMotor ticsDisruptive behaviorClinical concernPosttreatment assessmentBehavioral therapyWeekly sessionsAnxiety disordersTherapy treatmentSyndromeNeurodevelopmental disordersSignificant decreaseDefiant disorderInitial assessmentDisordersAggressive behaviorChapter 12 Assessing and Treating Emotion Dysregulation and Anger Management
Piasecka J, Bertschinger E, Tudor M, Sukhodolsky D. Chapter 12 Assessing and Treating Emotion Dysregulation and Anger Management. 2018, 255-277. DOI: 10.1016/b978-0-12-811980-8.00012-1.ChaptersEmotion dysregulationAnger outburstsCognitive problem-solving skillsCognitive-behavioral interventionsMost research supportProblem-solving skillsTourette syndromeEmotion regulationParent trainingBehavioral difficultiesAnger managementYoung childrenCase illustrationCurrent researchResearch supportChildrenFunctional impairmentChronic ticsPractical strategiesIndividualsDysregulationSkillsChapter 12ImpairmentTraining
2017
Moderators and predictors of response to behavior therapy for tics in Tourette syndrome
Sukhodolsky DG, Woods DW, Piacentini J, Wilhelm S, Peterson AL, Katsovich L, Dziura J, Walkup JT, Scahill L. Moderators and predictors of response to behavior therapy for tics in Tourette syndrome. Neurology 2017, 88: 1029-1036. PMID: 28202705, PMCID: PMC5384839, DOI: 10.1212/wnl.0000000000003710.Peer-Reviewed Original ResearchConceptsPredictors of responseChronic tic disorderTic reductionTic disordersPsychiatric disordersYale Global Tic Severity Scale-Total Tic ScoreTic severityTourette syndromeClinical Global Impressions-Improvement scoreCo-occurring psychiatric disordersAnxiety disordersSubgroup of patientsTotal tic scoreMain outcome measuresPredictors of outcomeBehavior therapyComprehensive Behavioral InterventionAttention-deficit/hyperactivity disorderPremonitory urge severityReduction of ticsCo-occurring attention-deficit/hyperactivity disorderGreater tic severityTIC characteristicsTic improvementClinical characteristicsTics and Tourette Syndrome
Sukhodolsky D, Gladstone T, Kaushal S, Piasecka J, Leckman J. Tics and Tourette Syndrome. Autism And Child Psychopathology Series 2017, 241-256. DOI: 10.1007/978-3-319-71210-9_14.ChaptersHabit reversal trainingTourette syndromeBehavioral interventionsPathophysiology of TSComprehensive clinical careComprehensive Behavioral InterventionCore clinical characteristicsAttention-deficit/hyperactivity disorderModerators of responseCo-occurring conditionsDisruptive behavior disordersClinical characteristicsChronic motorClinical efficacyTic expressionVocal ticsClinical recommendationsCo-occurring psychopathologyClinical careTic severityTreatment approachesPremonitory urgesBehavior disorderAnxiety disordersDiagnostic assessment
2014
Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome
McGuire JF, Sukhodolsky DG, Bearss K, Grantz H, Pachler M, Lombroso PJ, Scahill L. Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome. Child Psychiatry & Human Development 2014, 45: 686-694. PMID: 24477478, DOI: 10.1007/s10578-014-0437-7.Peer-Reviewed Original Research
2013
Social and Adaptive Functioning in Tourette Syndrome
Sukhodolsky D, Eicher V, Leckman J. Social and Adaptive Functioning in Tourette Syndrome. 2013, 468-484. DOI: 10.1093/med/9780199796267.003.0021.ChaptersPhenomenology of Tics and Sensory Urges: The Self Under Siege
Leckman J, Bloch M, Sukhodolsky D, Scahill L, King R. Phenomenology of Tics and Sensory Urges: The Self Under Siege. 2013, 3-25. DOI: 10.1093/med/9780199796267.003.0001.Peer-Reviewed Original ResearchAcademic outcomesComorbid behavioral problemsNovel behavioral interventionKey phenomenological featuresCognitive domainsIrrelevant informationBehavioral problemsBehavioral interventionsPhenomenology of ticsTourette syndromeLong-term outcomesPhenomenological featuresTic expressionTic disordersEnvironmental contextReduced abilitySensory urgeOutside worldRelated disordersEducational objectivesPhenomenological spectrumHabit reversal training for the treatment of tics in Tourette syndrome
Kapci E, Sukhodolsky D. Habit reversal training for the treatment of tics in Tourette syndrome. Anatolian Journal Of Psychiatry 2013, 14: 167. DOI: 10.5455/apd.35928.Peer-Reviewed Original Research
2012
Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome
Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L. Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome. JAMA Psychiatry 2012, 69: 795-803. PMID: 22868933, PMCID: PMC3772729, DOI: 10.1001/archgenpsychiatry.2011.1528.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionTic Severity ScaleTourette syndromeBehavior therapySeverity ScaleBehavioral interventionsOutpatient research clinicTotal tic scoreLeast moderate severityChronic tic disorderGreater mean decreaseMonthly booster sessionsAdult patientsSupportive treatmentModerate severityTic scoreTic disordersPositive respondersResearch clinicBooster sessionsMean decreasePosttreatment evaluationPatients
2010
Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder
Sukhodolsky D, LanderosWeisenberger A, Scahill L, Leckman J, Schultz R. Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1155-1164.e1. DOI: 10.1097/00004583-201011000-00009.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderConnors' Continuous Performance TestVisual-Motor Integration TestVisual-motor integrationContinuous Performance TestNeuropsychological functioningResponse inhibitionHyperactivity disorderCo-occurring attention-deficit/hyperactivity disorderStroop Color-Word Interference TestColor-Word Interference TestBeery Visual-Motor Integration TestAdequate control conditionsSample of childrenFine motor coordinationTourette syndromeNeuropsychological measuresPurdue Pegboard TestHealthy community control subjectsSubtle deficitsNeurobiological mechanismsNeuropsychological deficitsInterference testControl conditionPegboard TestNeuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder
Sukhodolsky DG, Landeros-Weisenberger A, Scahill L, Leckman JF, Schultz RT. Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1155-1164.e1. PMID: 20970703, PMCID: PMC2965169, DOI: 10.1016/j.jaac.2010.08.008.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderConnors' Continuous Performance TestVisual-Motor Integration TestVisual-motor integrationContinuous Performance TestNeuropsychological functioningResponse inhibitionHyperactivity disorderCo-occurring attention-deficit/hyperactivity disorderStroop Color-Word Interference TestColor-Word Interference TestBeery Visual-Motor Integration TestAdequate control conditionsSample of childrenFine motor coordinationTourette syndromeNeuropsychological measuresPurdue Pegboard TestHealthy community control subjectsSubtle deficitsNeurobiological mechanismsNeuropsychological deficitsInterference testControl conditionPegboard Test