2013
Functional modulation of mitochondrial cytochrome c oxidase underlies adaptation to high-altitude hypoxia in a Tibetan migratory locust
Zhang ZY, Chen B, Zhao DJ, Kang L. Functional modulation of mitochondrial cytochrome c oxidase underlies adaptation to high-altitude hypoxia in a Tibetan migratory locust. Proceedings Of The Royal Society B 2013, 280: 20122758. PMID: 23390104, PMCID: PMC3574369, DOI: 10.1098/rspb.2012.2758.Peer-Reviewed Original ResearchConceptsCytochrome c oxidaseOxidative phosphorylationLocust populationsHypoxia responseMigratory locustHypoxia toleranceC oxidaseMitochondrial cytochrome c oxidaseElectron transport rateElevated catalytic efficiencyHigher hypoxia toleranceCatalytic redox centerHypoxia adaptationCOX activityMitochondrial structureAerobic organismsFlight musclesMitochondrial mechanismsNovel mechanismLocusta migratoriaLocustFunctional modulationPermanent hypoxiaHypoxic treatmentProtein content
2012
Genome-wide analysis of transcriptional changes in the thoracic muscle of the migratory locust, Locusta migratoria, exposed to hypobaric hypoxia
Zhao D, Zhang Z, Harrison J, Kang L. Genome-wide analysis of transcriptional changes in the thoracic muscle of the migratory locust, Locusta migratoria, exposed to hypobaric hypoxia. Journal Of Insect Physiology 2012, 58: 1424-1431. PMID: 22985864, DOI: 10.1016/j.jinsphys.2012.08.006.Peer-Reviewed Original ResearchConceptsAnalysis of transcriptional changesHypoxia-inducible factorGenome-wide analysisPentose phosphate pathwayThoracic musclesPhosphate pathwayEndoplasmic reticulumMitochondrial biogenesisTranscriptional changesTranscriptional profilesDysfunctional proteinsTarget genesMitochondrial activityBiological response to hypoxiaMigratory locustLiving organismsResponse to hypoxiaLocusta migratoriaHigh-altitude regionsBiological responsesOxidative stressBiogenesisImpact of hypobaric hypoxiaPentoseInvertebrates