Featured Publications
Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisMicroenvironment Cell Contribution to Lymphoma Immunity
Kumar D, Xu ML. Microenvironment Cell Contribution to Lymphoma Immunity. Frontiers In Oncology 2018, 8: 288. PMID: 30101129, PMCID: PMC6073855, DOI: 10.3389/fonc.2018.00288.Peer-Reviewed Original ResearchLymphoma-associated macrophagesMesenchymal stem/stromal cellsT cellsLymphoma microenvironmentStromal cellsMarkers of exhaustionImmune checkpoint blockadeRegulatory T cellsEra of immunotherapyNatural killer cellsAnti-tumor effectsStem/stromal cellsLymphoma immunityTim-3Adverse eventsCheckpoint blockadeDendritic cellsImmune dysfunctionKiller cellsPD-1Immune cellsMechanisms of resistanceImmune escapeTumor surveillanceLAG-3Clinicopathological Review of Micropapillary Urothelial Carcinoma
Kumar D, Adeniran AJ. Clinicopathological Review of Micropapillary Urothelial Carcinoma. Current Oncology Reports 2022, 24: 603-610. PMID: 35199295, DOI: 10.1007/s11912-022-01219-x.Peer-Reviewed Original ResearchConceptsMicropapillary urothelial carcinomaUrothelial carcinomaNew therapeutic strategiesModerate interobserver reproducibilityClinicopathological reviewUrothelial componentAggressive variantHistopathologic characteristicsClinical managementWorse outcomesERBB2 amplificationTherapeutic strategiesDiagnostic criteriaReviewThis reviewCarcinomaOptimal managementReproducible criteriaInterobserver reproducibilityGenetic findingsIntratumoral heterogeneityHigh rateMolecular featuresRecent reportsLacunar spacesReviewBenign lymph node microenvironment is associated with response to immunotherapy
Toki MI, Kumar D, Ahmed FS, Rimm DL, Xu ML. Benign lymph node microenvironment is associated with response to immunotherapy. Precision Clinical Medicine 2020, 3: 44-53. PMID: 35693430, PMCID: PMC8985791, DOI: 10.1093/pcmedi/pbaa003.Peer-Reviewed Original ResearchBenign lymph nodesLymph nodesT cellsQuantitative immunofluorescenceBenign lymphPD-L1Immune checkpoint blockade therapyMultiplexed quantitative immunofluorescenceHigh expressionCheckpoint blockade therapyMacrophage marker expressionSignificant differencesCytotoxic markersBlockade therapyBenign findingsCancer patientsLymphoid tissueImmune surveillanceTreatment responsePostmortem examinationImmunotherapyProliferation indexSplenic tissueB cellsPatients
2018
Corrigendum: Microenvironment Cell Contribution to Lymphoma Immunity
Kumar D, Xu ML. Corrigendum: Microenvironment Cell Contribution to Lymphoma Immunity. Frontiers In Oncology 2018, 8: 522. PMID: 30460201, PMCID: PMC6237016, DOI: 10.3389/fonc.2018.00522.Peer-Reviewed Original Research