Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisClinicopathological Review of Micropapillary Urothelial Carcinoma
Kumar D, Adeniran AJ. Clinicopathological Review of Micropapillary Urothelial Carcinoma. Current Oncology Reports 2022, 24: 603-610. PMID: 35199295, DOI: 10.1007/s11912-022-01219-x.Peer-Reviewed Original ResearchConceptsMicropapillary urothelial carcinomaUrothelial carcinomaNew therapeutic strategiesModerate interobserver reproducibilityClinicopathological reviewUrothelial componentAggressive variantHistopathologic characteristicsClinical managementWorse outcomesERBB2 amplificationTherapeutic strategiesDiagnostic criteriaReviewThis reviewCarcinomaOptimal managementReproducible criteriaInterobserver reproducibilityGenetic findingsIntratumoral heterogeneityHigh rateMolecular featuresRecent reportsLacunar spacesReview