Effect of Isoniazid Chemoprophylaxis on HIV-Related Mycobacterial Disease
Graham N, Galai N, Nelson K, Astemborski J, Bonds M, Rizzo R, Sheeley L, Vlahov D. Effect of Isoniazid Chemoprophylaxis on HIV-Related Mycobacterial Disease. JAMA Internal Medicine 1996, 156: 889-894. PMID: 8774208, DOI: 10.1001/archinte.1996.00440080089010.Peer-Reviewed Original ResearchConceptsM avium complexMycobacterial diseaseTuberculosis incidenceAvium complexCutaneous anergyIsoniazid chemoprophylaxisIsoniazid prophylaxisPreventive therapyRisk factorsIncidence rateCD4 lymphocyte cell countProspective observational cohort studyPPD-positive patientsTwice-weekly isoniazidWeeks of therapyObservational cohort studyLymphocyte cell countsMonths of diagnosisOverall incidence rateAnnual incidence ratePopulation-based dataStrong risk factorTuberculin-positive subjectsMycobacterium avium complexTuberculin-positive individuals