2002
Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users?
Kapadia F, Vlahov D, Jarlais D, Strathdee S, Ouellet L, Kerndt P, E E, Williams I, Garfein R. Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users? Epidemiology 2002, 13: 738-741. PMID: 12410020, DOI: 10.1097/00001648-200211000-00023.Peer-Reviewed Original ResearchConceptsInjection drug usersAnti-HCV seroconversionHepatitis C virusDrug usersOdds ratioBleach useYoung adult injection drug usersSeronegative injection drug usersMajor public health problemAdult injection drug usersBleach disinfectionHepatitis C infectionProspective cohort studyCase-control studyConditional logistic regressionPublic health problemCessation of injectionsC infectionHCV infectionCohort studyC virusProtective effectHealth problemsSeroconversionLogistic regression
2001
Needle-exchange participation, effectiveness, and policy: Syringe relay, gender, and the paradox of public health
Valente T, Foreman R, Junge B, Vlahov D. Needle-exchange participation, effectiveness, and policy: Syringe relay, gender, and the paradox of public health. Journal Of Urban Health 2001, 78: 340-349. PMID: 11419584, PMCID: PMC3456352, DOI: 10.1093/jurban/78.2.340.Peer-Reviewed Original ResearchMeSH KeywordsAdultBaltimoreCommerceCommunity Health PlanningCounselingFemaleHealth BehaviorHealth EducationHIV InfectionsHumansInterpersonal RelationsMaleMiddle AgedNeedle-Exchange ProgramsOrganizational ObjectivesProgram EvaluationSocial SupportSubstance Abuse, IntravenousSurveys and QuestionnairesSyringesUrban HealthConceptsNeedle exchange programsNEP useIntravenous drug usersBaltimore Needle Exchange ProgramPublic health goalsHIV seroconversionHIV protectionDrug usersHealth goalsVirus transmission rateHigh usersDuration of contactPublic healthEducation effortsCirculation timeMost studiesRelay activityExclusive useParticipantsSeroconversionHIVVisitsWomenSex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective
Strathdee S, Galai N, Safaiean M, Celentano D, Vlahov D, Johnson L, Nelson K. Sex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective. JAMA Internal Medicine 2001, 161: 1281-1288. PMID: 11371255, DOI: 10.1001/archinte.161.10.1281.Peer-Reviewed Original ResearchConceptsInjection drug usersIncidence of HIVHIV seroconversionRisk factorsProspective studyDrug usersHigh-risk heterosexual activityHuman immunodeficiency virus interventionsHIV-negative injection drug usersHuman immunodeficiency virus (HIV) infectionFemale injection drug usersImmunodeficiency virus infectionInjection drug useDrug-related risksHomosexual activityTime-dependent covariatesHIV testMedian agePerson yearsDaily injectionsNeedle sharingCocaine injectionHIV riskVirus infectionSeroconversion
2000
The prevalence of homelessness among injection drug users with and without HIV infection
Song J, Safaeian M, Strathdee S, Vlahov D, Celentano D. The prevalence of homelessness among injection drug users with and without HIV infection. Journal Of Urban Health 2000, 77: 678-687. PMID: 11194310, PMCID: PMC3456762, DOI: 10.1007/bf02344031.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusInjection drug usersInjection drug useIndependent predictorsDrug usersDrug useActive injection drug useLongitudinal cohort studyCross-sectional studyHIV/AIDSCross-sectional investigationHIV seroconversionCohort studyHIV seroprevalenceHIV infectionPrevalence of homelessnessImmunodeficiency virusMale sexLogistic regressionPrevalenceParticipantsMore experiencePredictorsSeroconversionSerostatus
1999
Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load
Lyles C, Dorrucci M, Vlahov D, Pezzotti P, Angarano G, Sinicco A, Alberici F, Alcorn T, Vella S, Rezza G. Longitudinal Human Immunodeficiency Virus Type 1 Load in the Italian Seroconversion Study: Correlates and Temporal Trends of Virus Load. The Journal Of Infectious Diseases 1999, 180: 1018-1024. PMID: 10479126, DOI: 10.1086/314980.Peer-Reviewed Original ResearchConceptsHIV-1 loadVirus loadHuman immunodeficiency virus type 1 (HIV-1) loadHuman immunodeficiency virus type 1 (HIV-1) seroconvertersCD4 cells/microL.Low CD4 cell countsItalian Seroconversion StudyCD4 cell countCells/microL.Injection drug useCourse of diseaseReverse transcriptase-polymerase chain reactionHigh virus loadTranscriptase-polymerase chain reactionClinical AIDSMale sexProspective studyDisease progressionSeroconversion StudyCell countDrug useSustained increaseSeroconversionAIDSFrozen serumSex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters
Sterling T, Lyles C, Vlahov D, Astemborski J, Margolick J, Quinn T. Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters. The Journal Of Infectious Diseases 1999, 180: 666-672. PMID: 10438353, DOI: 10.1086/314967.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 RNA levelsHIV-1 seroconvertersSex differencesCopies/mLHIV-1 pathogenesisInjection drug usersCase-control studyTime of seroconversionCross-sectional studyCourse of infectionMale patientsRapid progressorsFemale patientsCopies/Drug usersMale controlsVirus levelsPatientsRNA levelsSeroconvertersWomenMenNonprogressorsSeroconversionProgressorsNew evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users
Krol A, Flynn C, Vlahov D, Miedema F, Coutinho R, van Ameijden E. New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users. Drug And Alcohol Dependence 1999, 54: 145-154. PMID: 10217554, DOI: 10.1016/s0376-8716(98)00158-6.Peer-Reviewed Original Research
1996
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti P, Phillips A, Dorrucci M, Lepri A, Galai N, Vlahov D, Rezza G. Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. The BMJ 1996, 313: 583. PMID: 8806246, PMCID: PMC2352019, DOI: 10.1136/bmj.313.7057.583.Peer-Reviewed Original ResearchConceptsDate of seroconversionCategories of exposureExposure categoriesOlder subjectsInjected drugsMore rapid progressionHeterosexual sexLongitudinal studyHomosexual sexHIV treatmentAIDS pathogenesisUnivariate analysisRapid progressionAge effectsYoung subjectsHomosexual menHIVRate of developmentEvidence of differencesDisease controlAIDSSeroconversionSexAgeDefinitions of CenterDifferences in the Incidence of Hepatitis B and Human Immunodeficiency Virus Infections among Injecting Drug Users
Levine O, Vlahov D, Brookmeyer R, Cohn S, Nelson K. Differences in the Incidence of Hepatitis B and Human Immunodeficiency Virus Infections among Injecting Drug Users. The Journal Of Infectious Diseases 1996, 173: 579-583. PMID: 8627020, DOI: 10.1093/infdis/173.3.579.Peer-Reviewed Original ResearchConceptsHepatitis B virusHBV seroconversionOutcome measuresDrug usersHuman immunodeficiency virus type 1 (HIV-1) seroconversionIncident hepatitis B virusHuman immunodeficiency virus (HIV) infectionHIV seroconversion ratesHIV-seronegative IDUsSubsequent HIV seroconversionImmunodeficiency virus infectionInjecting Drug UsersSurrogate outcome measureImportant outcome measureNeedle exchange programsMale IDUsHIV seroconversionIncident HIVSeroconversion ratesHepatitis BHIV infectionFemale IDUsB virusVirus infectionSeroconversionTemporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992
Galai N, Lepri A, Vlahov D, Pezzotti P, Sinicco A, Rezza G, Study H. Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992. American Journal Of Epidemiology 1996, 143: 278-282. PMID: 8561162, DOI: 10.1093/oxfordjournals.aje.a008739.Peer-Reviewed Original ResearchConceptsCD4 cell measurementsInitial CD4 cell countHuman immunodeficiency virus (HIV) seroconversionCD4 cell countCell countCD4 cell count increaseItalian Seroconversion StudyLow CD4 countMonths of seroconversionYear of seroconversionCD4 cell levelsCell count increaseMedian lag timeCD4 countCD4 levelsHIV seroconversionPositive serologyNegative serologyHIV seroconvertersClinical centersRisk groupsSeroconversion StudySeroconversionMultivariate modelLag time
1995
Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes.
Holmberg S, Conley L, Luby S, Cohn S, Wong L, Vlahov D. Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 291. PMID: 7788428, DOI: 10.1097/00042560-199507000-00011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 T lymphocytesObservational cohort studyT lymphocytesCell countHIV seroconversionCohort studyHIV infectionImmunodeficiency virusOngoing observational cohort studyEarlier calendar yearsMore rapid declineLow CD4Mean CD4Recent infectionHIV-1CD4Drug usersBisexual menInfectionSeroconversionCalendar yearLymphocytesRapid lossFirst yearClinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users
Dorrucci M, Rezza G, Vlahov D, Pezzotti P, Sinicco A, Nicolosi A, Lazzarin A, Galai N, Gafà S, Pristerà R. Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users. AIDS 1995, 9: 597-604. PMID: 7662199, DOI: 10.1097/00002030-199506000-00011.Peer-Reviewed Original ResearchConceptsAcute retroviral syndromeHIV infectionHIV seroconvertersRelative hazardDrug usersFirst positive HIV testYear of seroconversionPositive HIV testRate of CD4Kaplan-Meier estimatesCumulative AIDS incidenceAsymptomatic seroconvertersHIV seroconversionClinical characteristicsHIV testClinical progressionPrognostic valueProspective studyClinical centersSeroconvertersCell declineSeroconversionCell countSyndromeNatural historyIncidence and Risk Factors for Human T-Lymphotropic Virus Type II Seroconversion Among Injecting Drug Users in Baltimore, Maryland, U.S.A
Vlahov D, Khabbaz R, Cohn S, Galai N, Taylor E, Kaplan J. Incidence and Risk Factors for Human T-Lymphotropic Virus Type II Seroconversion Among Injecting Drug Users in Baltimore, Maryland, U.S.A. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 89-96. PMID: 7712239, DOI: 10.1097/00042560-199505010-00013.Peer-Reviewed Original ResearchConceptsRisk factorsDrug usersEnzyme immunoassayWestern blotHuman T-lymphotropic virusNeedle-sharing practicesRisk factor analysisT-lymphotropic virusMedian lag timeCase-control designALIVE studyRecent serumSeronegative IDUsStudy entryBaseline historyIncidence rateSeroconversionPositive casesSex partnersIDUsHTLVCalendar timeMonthsIncidenceBaselineChanges in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates
1994
Field effectiveness of needle disinfection among injecting drug users.
Vlahov D, Astemborski J, Solomon L, Nelson K. Field effectiveness of needle disinfection among injecting drug users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1994, 7: 760-6. PMID: 8207660.Peer-Reviewed Original ResearchConceptsHIV seroconversionOdds ratioDrug usersNeedle disinfectionPutative protective effectCase-control studyCorresponding odds ratiosSterile injection equipmentDisinfectant useInjection equipmentLimited statistical powerStudy entryHIV seroconvertersResidual confoundingPossible confoundersCocaine injectionProtective effectSeroconversionDrug useUse of disinfectantsBlack heterosexualsPractice variablesField effectivenessSeroconvertersSeronegativesMaturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users
Alcabes P, Muñoz A, Vlahov D, Friedland G. Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users. Annals Of Epidemiology 1994, 4: 17-26. PMID: 7911376, DOI: 10.1016/1047-2797(94)90038-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBaltimoreCD4-Positive T-LymphocytesCohort StudiesConfidence IntervalsHIV InfectionsHIV SeroprevalenceHomosexualityHumansIncidenceLeukocyte CountLife TablesMaleModels, StatisticalNew York CityPlatelet CountRegression AnalysisSubstance Abuse, IntravenousSurvival RateTime FactorsConceptsHIV infectionDrug usersImmunodeficiency syndromeMedian timeCombined cohortHomosexual menHuman immunodeficiency virus (HIV) infectionHuman immunodeficiency virus (HIV) epidemicPercent of CD4Immunodeficiency virus infectionIncident HIV infectionProduct-limit methodMarkers of maturityHIV incubation distributionsPlatelet countVirus infectionLarge cohortSeroconversionCohortInfectionConfidence intervalsIncubation distributionAIDSVirus epidemicPopulation groups
1993
Differences in Risk Factors for Human Immunodeficiency Virus Type 1 Seroconversion among Male and Female Intravenous Drug Users
Solomon L, Astemborski J, Warren D, Muñoz A, Cohn S, Vlahov D, Nelson K. Differences in Risk Factors for Human Immunodeficiency Virus Type 1 Seroconversion among Male and Female Intravenous Drug Users. American Journal Of Epidemiology 1993, 137: 892-898. PMID: 8484380, DOI: 10.1093/oxfordjournals.aje.a116750.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus type 1 (HIV-1) seroconversionDrug usersSeronegative controlsRisk factorsFemale intravenous drug usersMale intravenous drug usersSex-specific risk factorsCurrent intravenous drug useHIV-seronegative controlsIntravenous drug useRisk of seroconversionRisk factor dataCase-control studyAge 18 yearsConditional logistic regression techniquesTime of interviewMore sex partnersSeroconversion statusSeroconversion visitHIV seroconversionHIV infectionStudy entrySexual transmissionSeroconversion
1991
HIV SEROCONVERSION AND DISINFECTION OF INJECTION EQUIPMENT AMONG INTRAVENOUS DRUG USERS, BALTIMORE, MARYLAND
Vlahov D, Muntoz A, Celentano D, Cohn S, Anthony J, Chiicoat H, Nelson K. HIV SEROCONVERSION AND DISINFECTION OF INJECTION EQUIPMENT AMONG INTRAVENOUS DRUG USERS, BALTIMORE, MARYLAND. Epidemiology 1991, 2: 444-446. PMID: 1790197, DOI: 10.1097/00001648-199111000-00010.Peer-Reviewed Original ResearchConceptsIntravenous drug usersDrug usersHIV seroconversionProtective effectUse of disinfectantsPutative protective effectCase-control studyCorresponding odds ratiosOdds of seroconversionDisinfectant useLimited protective effectUse of cocaineStudy entryHIV seroconvertersOdds ratioSeroconversionInjection equipmentOddsSeroconvertersSeronegativesDisinfectants