Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
Shin H, Winkler C, Stephens J, Bream J, Young H, Goedert J, O'Brien T, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien S, Smith M. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14467-14472. PMID: 11121048, PMCID: PMC18942, DOI: 10.1073/pnas.97.26.14467.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 replicationTranscription factor recognition sequencePromoter allelesLong-term nonprogressorsHIV-1 pathogenesisSingle nucleotide polymorphic variantsOnset of AIDSMacrophages/monocytesNuclear transcription factorSignificant genotype associationsIL10 promoter regionShort tandem repeat polymorphismsTranscription factorsPromoter regionRecognition sequenceIL10 productionInflammatory cytokinesCell cytokinesAIDS cohortC genotypeLymphoid cellsPromoter genotypeGenetic restrictionLymphocyte replication